Review
Nature Reviews Immunology 2, 227-238 (April 2002) | doi:10.1038/nri774
Subject Category: Vaccines
Vaccines: Spinning molecular immunology into successful immunotherapy
Drew M. Pardoll1 About the author
Abstract
Until recently, immunotherapies have been of limited success, particularly against cancer. However, recent insights into the cells, molecules and signalling pathways that regulate immune responsiveness are providing new approaches for immunotherapy. In this article, I review some of the most promising molecular and cellular targets for immunotherapy and discuss approaches that use these targets to amplify immune responses and potentially break antigen-specific tolerance. These strategies provide a blueprint for the development of successful immunotherapy over the next decade.
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Author affiliations
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Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA.
Email: dmpardol@jhmi.edu
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