Review
Nature Reviews Immunology 2, 85-95 (February 2002) | doi:10.1038/nri724
Epitope spreading in immune-mediated diseases: implications for immunotherapy
Carol L. Vanderlugt1 & Stephen D. Miller1 About the authors
Abstract
Evidence continues to accumulate supporting the hypothesis that tissue damage during an immune response can lead to the priming of self-reactive T and/or B lymphocytes, regardless of the specificity of the initial insult. This review will focus primarily on epitope spreading at the T-cell level. Understanding the cellular and molecular basis of epitope spreading in various chronic immune-mediated human diseases and their animal models is crucial to understanding the pathogenesis of these diseases and to the ultimate goal of designing antigen-specific treatments.
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Author affiliations
- Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Medical School, 303 E. Chicago Avenue, Chicago, IL 60611, USA
Correspondence to: Stephen D. Miller1 Email: s-d-miller@northwestern.edu
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