Review
Nature Reviews Immunology 2, 965-975 (December 2002) | doi:10.1038/nri957
A blast from the past: clearance of apoptotic cells regulates immune responses
John Savill1, Ian Dransfield1, Chris Gregory1 & Chris Haslett1 About the author
Abstract
Apoptosis, which is a programmed and physiological form of cell death, is known to shape the immune system by regulating populations of effector lymphocytes. However, the binding and ingestion of dying cells by monocytes/macrophages and dendritic cells can also influence immune responses markedly by enhancing or suppressing inflammation. Therefore, dead cells, which are a reflection of an organism's immediate past, can control its immunological future.
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Author affiliations
- MRC/University of Edinburgh Centre for Inflammation Research, Departments of Clinical & Surgical Sciences (Internal Medicine) and Medical & Radiological Sciences (Respiratory Medicine), Royal Infirmary, Lauriston Place, Edinburgh EH3 9YW, UK.
Correspondence to: John Savill1 Email: J.Savill@ed.ac.uk
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