Review
Nature Reviews Immunology 2, 945-956 (December 2002) | doi:10.1038/nri955
Focus on: Decision making in the immune system
Regulation of B-cell fate by antigen-receptor signals
Hiroaki Niiro1 & Edward A. Clark1 About the authors
Abstract
Recent evidence indicates that B cells are instructed continuously by B-cell receptor (BCR) signals to make crucial cell-fate decisions at several checkpoints during their development. Targeted disruption of BCR signalling components leads to distinct blocks in B-cell maturation, which indicates that key kinases and adaptors fine-tune BCR signalling to direct appropriate cell fates. Recent progress in unravelling the molecular mechanisms of the BCR signalling pathways has helped to clarify how BCR signals regulate the proliferation, survival and apoptosis of developing B cells.
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Author affiliations
- Departments of Microbiology and Immunology, University of Washington, Seattle, Washington 98195, USA.
Correspondence to: Edward A. Clark1 Email: eclark@bart.rprc.washington.edu
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