Perspectives
Nature Reviews Immunology 2, 888-897 (November 2002) | doi:10.1038/nri937
Opinion: A positive look at double-negative thymocytes
Rod Ceredig1 About the author & Ton Rolink2
Abstract
In some respects, our understanding of the cellular and molecular aspects of early T-cell differentiation is lagging behind that of B cells. Papers describing gene-knockout and reporter-transgenic mice in which thymocyte development is affected are often difficult to interpret. Progress in this field will be hampered unless a more detailed phenotypic and molecular analysis of progenitor thymocytes at the single-cell level is carried out.
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Author affiliations
- Rod Ceredig is at U548 INSERM, CEA-G, 17 rue des Martyrs, F-38054 Grenoble, France.
- Ton Rolink is at the Department of Immunology, University of Basel, Pharmacenter, Klingelbergstrasse 50–70, CH-4065 Basel, Switzerland.
Correspondence to: Rod Ceredig1 Email: ceredig@dsvsud.cea.fr
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