Review
Nature Reviews Immunology 2, 859-871 (November 2002) | doi:10.1038/nri934
Stem cell medicine encounters the immune system
J. Andrew Bradley1, Eleanor M. Bolton1 & Roger A. Pedersen1 About the authors
Abstract
Recent progress in deriving human embryonic stem (hES) cells and defining their capacity to differentiate has inspired hope that they could become a source of replacement cells for damaged or diseased tissues. We review the immunological barriers to transplanting hES cells and consider several potential solutions, including stem-cell banking, modification of the immunogenicity of donor cells and induction of tolerance to the graft. We evaluate the probable efficacy of these approaches with a view to facilitating the use of hES cells in clinical practice.
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Author affiliations
- Department of Surgery, Cambridge University Clinical School, Addenbrooke's Hospital, Cambridge CB2 2QQ, UK.
Correspondence to: J. Andrew Bradley1 Email: jab52@cam.ac.uk
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