Review
Nature Reviews Immunology 2, 787-795 (October 2002) | doi:10.1038/nri915
Anti-inflammatory lipid mediators and insights into the resolution of inflammation
Toby Lawrence1,2, Derek A. Willoughby2 & Derek W. Gilroy2 About the authors
Abstract
The pro-inflammatory signalling pathways and cellular mechanisms that initiate the inflammatory response have become increasingly well characterized. However, little is known about the mediators and mechanisms that switch off inflammation. Recent data indicate that the resolution of inflammation is an active process controlled by endogenous mediators that suppress pro-inflammatory gene expression and cell trafficking, as well as induce inflammatory-cell apoptosis and phagocytosis, which are crucial determinants of successful resolution. This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines.
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Author affiliations
- Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0636, USA.
- Department of Experimental Pathology, William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, University of London, Charterhouse Square, London EC1M 6BQ, UK.
Correspondence to: Toby Lawrence1,2 Email: tolawrence@ucsd.edu
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