Review
Nature Reviews Immunology 2, 748-759 (October 2002) | doi:10.1038/nri912
Emerging roles of PPARS in inflammation and immunity
Raymond A. Daynes1,2 & Dallas C. Jones1 About the authors
Abstract
Lipids and lipid metabolism have well-documented regulatory effects on inflammatory processes. Recent work has highlighted the role of the peroxisome proliferator-activated receptors (PPARs) — a subset of the nuclear-hormone-receptor superfamily that are activated by various lipid species — in regulating inflammatory responses. Here, we describe how the PPARs, through their interactions with transcription factors and other cell-signalling systems, have important regulatory roles in innate and adaptive immunity.
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Author affiliations
- Department of Pathology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, Utah 84132-2501, USA.
- Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah 84112, USA.
Correspondence to: Raymond A. Daynes1,2 Email: daynes.office@path.utah.edu
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