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Ashley Moffett describes a 1995 paper by Colonna and Samaridis that provided the stimulus to understanding the link between NK cells and pre-eclampsia.
Intracellular and secreted isoforms of osteopontin differentially regulate myeloid progenitors and differentiated lymphoid cells, respectively, through pro- and anti-apoptotic effects.
Two groups have shown that personalized, neoantigen-based tumour vaccines elicit effective T cell responses in patients with advanced melanoma, leading to favourable clinical outcomes. Combination with checkpoint blockade can be of additional benefit.
Although healthy pregnancies were traditionally considered to require an anti-inflammatory state, emerging evidence suggests that inflammation is important for a healthy pregnancy. Here, the authors discuss how the immune response varies throughout the main stages of pregnancy, and they consider how bacterial and viral infections can affect immune responses at the maternal–fetal interface.
This Review discusses how genetically discordant microchimeric cells transferred between a mother and her offspring during pregnancy have important implications for definitions of immunological identity and tolerance.
Why are newborns more vulnerable to infection? Here, the authors explain that it is not the immaturity of the immune system per se, but the unique regulation of immune responses in early life that limits immunity to infection yet allows safe developmentin uteroand the accommodation of microbial colonization at birth.
Accumulating evidence suggests that environmental experiences during childhood can result in the development of allergies that persist into adulthood. In this Review, the authors present the evidence for specific early life exposures that may tip the balance between tolerance and allergic sensitization.
