Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 17 Issue 7, July 2017

'BACH tuning of the immune system' by Simon Bradbrook, inspired by the Review on p437.

Research Highlight

  • T-bet+ regulatory T cells form a stable subset with specific suppressive activity towards T-bet+effector T cells.

    • Kirsty Minton
    Research Highlight

    Advertisement

  • Regulatory T cells modulate the hair follicle regeneration cycle by inducing stem cell proliferation and differentiation.

    • Shimona Starling
    Research Highlight
  • Lambda interferons have a non-redundant role in protecting airway epithelial cells from influenza A virus infection without inducing immunopathology.

    • Kirsty Minton
    Research Highlight
Top of page ⤴

Journal Club

  • Anne Cooke discusses a 1989 paper by Don Mason and colleagues that described a role for adrenal corticosteroids in modulating autoimmune pathology.

    • Anne Cooke
    Journal Club
Top of page ⤴

Research Highlight

  • Sphingosine 1-phosphate promotes naive T cell survival by supporting their mitochondrial function.

    • Yvonne Bordon
    Research Highlight
Top of page ⤴

Review Article

  • Sepsis — which is caused by a dysregulated host response to infection — is a life-threatening organ dysfunction. This Review describes the recent advances in our understanding of sepsis pathogenesis and discusses strategies for the development of successful therapies.

    • Tom van der Poll
    • Frank L. van de Veerdonk
    • Mihai G. Netea
    Review Article
  • In this Review, the authors propose that disease-associated genetic variants modulate signalling downstream of B cell receptors, Toll-like receptors and cytokine receptors in B cells to drive autoimmune responses. This altered signalling favours a naive B cell repertoire that is skewed towards self-reactivity and promotes the peripheral activation of autoreactive B cell clones.

    • David J. Rawlings
    • Genita Metzler
    • Shaun W. Jackson
    Review Article
  • The transcriptional repressors BTB and CNC homology 1 (BACH1) and BACH2 compete with transcriptional activators of the basic region leucine zipper (bZIP) family to control widespread functions of the innate and adaptive immune systems.

    • Kazuhiko Igarashi
    • Tomohiro Kurosaki
    • Rahul Roychoudhuri
    Review Article
Top of page ⤴

Opinion

  • In this Opinion article, the authors discuss the limitations of categorizing tissue-resident macrophages based on their ontogeny. Instead, they propose that competition for a limited number of tissue niches may serve as a better framework for understanding the origins and functions of tissue macrophages.

    • Martin Guilliams
    • Charlotte L. Scott
    Opinion
Top of page ⤴

Search

Quick links