Current Issue


Comment: Emil von Behring: translational medicine at the dawn of immunology

Stefan H. E. Kaufmann

p341 | doi:10.1038/nri.2017.37

Remembering Emil von Behring, one of the founders of immunology, 100 years after his death.

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Research Highlights

Immune regulation: IL-10 targets macrophage metabolism | PDF (106 KB)

p345 | doi:10.1038/nri.2017.57

The anti-inflammatory effects of IL-10 involve mTORC1-regulated metabolic and autophagic pathways in macrophages.

Neuroimmunology: Macrophages help you burn energy | PDF (1,642 KB)

p346 | doi:10.1038/nri.2017.56

Macrophages in brown adipose tissue support sympathetic innervation to ensure proper homeostatic energy expenditure.

Asthma and allergy: The NET effect of respiratory viruses | PDF (2,773 KB)

p346 | doi:10.1038/nri.2017.60

Rhinovirus infections exacerbate asthma by inducing the release of neutrophil extracellular traps.

Tumour immunology: Immune atlas sheds light on anticancer responses | PDF (101 KB)

p347 | doi:10.1038/nri.2017.59

Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.

Journal Club

Medullary Thymic epithelial cell progenitors: hidden in plain sight | PDF (88 KB)

p348 | doi:10.1038/nri.2017.27

Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors.

Tumour immunology: Platelets — a new target in cancer immunotherapy? | PDF (133 KB)

p348 | doi:10.1038/nri.2017.61

Activation of TGFβ by platelets limits the efficacy of anti-tumour T cell responses.

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Reviews

Monocyte differentiation and antigen-presenting functions

Claudia V. Jakubzick, Gwendalyn J. Randolph & Peter M. Henson

p349 | doi:10.1038/nri.2017.28

Monocytes not only serve as precursors for macrophages, but also contribute to tissue immunity by presenting antigen to T cells and producing immunomodulatory mediators. In this Review, the authors discuss some of these less well-appreciated immune functions of monocytes.

Mitochondrial DNA in innate immune responses and inflammatory pathology

A. Phillip West & Gerald S. Shadel

p363 | doi:10.1038/nri.2017.21

Mitochondrial DNA (mtDNA) can engage multiple pattern-recognition receptors to trigger pro-inflammatory and type I interferon responses. This Review provides an overview of how these responses are activated by summarizing the unique features of mtDNA and how it is exposed during cellular stress.

Multi-receptor detection of individual bacterial products by the innate immune system

Karen J. Kieser & Jonathan C. Kagan

p376 | doi:10.1038/nri.2017.25

The detection of cell wall components has a critical role in the recognition of bacteria and the initiation of host defence. In this Review, Kieser and Kagan discuss common themes associated with the detection of individual bacterial products by diverse receptors of the innate immune system.

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Perspectives

Opinion

Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them

Jason T. White, Eric W. Cross & Ross M. Kedl

p391 | doi:10.1038/nri.2017.34

In this Opinion article, the authors discuss our growing appreciation of antigen-inexperienced memory T cell subsets. They focus on the development and functions of the recently described 'virtual memory' and 'innate memory' CD8+ T cell populations, and propose a unified nomenclature for these subsets.

Correspondence

Correspondence: Immunosuppressive cell death in cancer

Jiajie Hou, Tim F. Greten & Qiang Xia

p401 | doi:10.1038/nri.2017.46

Correspondence: Immunosuppressive cell death in cancer

Lorenzo Galluzzi, Aitziber Buqué, Oliver Kepp, Laurence Zitvogel & Guido Kroemer

p402 | doi:10.1038/nri.2017.48