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Multiscale immune profiling strategies facilitate unprecedented insights into the subtypes and composition of immune cells in the tumour microenvironment.
Graham Anderson describes a 2001 study by Rodewald and colleagues that provided the first experimental evidence for thymic epithelial cell progenitors.
Monocytes not only serve as precursors for macrophages, but also contribute to tissue immunity by presenting antigen to T cells and producing immunomodulatory mediators. In this Review, the authors discuss some of these less well-appreciated immune functions of monocytes.
Mitochondrial DNA (mtDNA) can engage multiple pattern-recognition receptors to trigger pro-inflammatory and type I interferon responses. This Review provides an overview of how these responses are activated by summarizing the unique features of mtDNA and how it is exposed during cellular stress.
The detection of cell wall components has a critical role in the recognition of bacteria and the initiation of host defence. In this Review, Kieser and Kagan discuss common themes associated with the detection of individual bacterial products by diverse receptors of the innate immune system.
In this Opinion article, the authors discuss our growing appreciation of antigen-inexperienced memory T cell subsets. They focus on the development and functions of the recently described 'virtual memory' and 'innate memory' CD8+T cell populations, and propose a unified nomenclature for these subsets.
