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Volume 17 Issue 2, February 2017

'Decoy duck' by Simon Bradbrook, inspired by the Review on p112.

Research Highlight

  • Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease.

    • Kirsty Minton
    Research Highlight

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  • NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K–AKT–mTOR pathway.

    • Olive Leavy
    Research Highlight
  • Plasma cells accumulate in the ageing thymus and may provide protection against viral infections.

    • Yvonne Bordon
    Research Highlight
  • Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure.

    • Lydia Shipman
    Research Highlight
  • Chewing induces the accumulation of T helper 17 cells in the mouth.

    • Lucy Bird
    Research Highlight
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Review Article

  • Disease tolerance is a defence strategy that functions by improving tissue repair or by reducing the detrimental effect of inflammatory signals to prevent the harmful effects of pathogens. This Review describes the mechanisms underlying disease tolerance to infections and how these can be targeted therapeutically.

    • Miguel P. Soares
    • Luis Teixeira
    • Luis F. Moita
    Review Article
  • Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?

    • Lorenzo Galluzzi
    • Aitziber Buqué
    • Guido Kroemer
    Review Article
  • In this Review, the authors summarize recent findings that illustrate the emerging roles of CCCH zinc finger proteins, which are involved in the regulation of multiple steps of RNA metabolism, in the regulation of immune responses including cytokine production, immune cell activation and immune homeostasis.

    • Mingui Fu
    • Perry J. Blackshear
    Review Article
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Correspondence

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