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Increased expression of inflammasome-related gene modules in older individuals correlates with nucleotide metabolism dysfunction, IL-1β production and cardiovascular disease.
NLRC3 protects against colorectal cancer by suppressing the proliferation of intestinal epithelial cells through inhibition of the PI3K–AKT–mTOR pathway.
Interleukin-33 is a key driver of type 2 immunity in the developing neonatal lung of mice both in the steady state and in response to allergen exposure.
Disease tolerance is a defence strategy that functions by improving tissue repair or by reducing the detrimental effect of inflammatory signals to prevent the harmful effects of pathogens. This Review describes the mechanisms underlying disease tolerance to infections and how these can be targeted therapeutically.
Initiation of an adaptive immune response depends on the detection of both antigenic epitopes and adjuvant signals. Infectious pathogens and cancer cells often avoid immune detection by limiting the release of danger signals from dying cells. When is cell death immunogenic and what are the pathophysiological implications of this process?
Understanding how decoy receptors for cytokines and chemokines work requires in-depth insights into their structure. In this Review, the authors provide a structural overview of both mammalian and viral decoy receptors and highlight opportunities for leveraging their immunomodulatory activity for therapeutic purposes.
In this Review, the authors summarize recent findings that illustrate the emerging roles of CCCH zinc finger proteins, which are involved in the regulation of multiple steps of RNA metabolism, in the regulation of immune responses including cytokine production, immune cell activation and immune homeostasis.