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Volume 16 Issue 5, May 2016

'Branching out' by Simon Bradbrook, inspired by the Review on p279.

Research Highlight

  • Peritoneal cavity macrophages are rapidly recruited by a non-vascular route to the injured liver to mediate tissue repair.

    • Kirsty Minton
    Research Highlight

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  • Arginase 1 regulates ILC2 metabolism and the development of type 2 inflammation in the lungs.

    • Yvonne Bordon
    Research Highlight
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Journal Club

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Research Highlight

  • Asymmetric distribution of metabolic pathway components sustains differential CD8+T cell fates.

    • Olive Leavy
    Research Highlight
  • Circulating tumour cells fragment as they metastasize, providing 'information' to immune cells that promote or inhibit metastasis.

    • Lucy Bird
    Research Highlight
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Review Article

  • This Review details the key roles of microRNAs (miRNAs) in regulating immune cell development and function. The authors describe how miRNAs govern cell fate decisions during haematopoiesis and discuss how aberrant miRNA expression can lead to pathologies such as autoimmunity and cancer.

    • Arnav Mehta
    • David Baltimore
    Review Article
  • In this Review, the authors describe the diversity and characteristics of tissue-resident human natural killer cells, with focus on those found in the liver, uterus and lungs. They also discuss important unresolved questions and future challenges in the field.

    • Niklas K. Björkström
    • Hans-Gustaf Ljunggren
    • Jakob Michaëlsson
    Review Article
  • In this Review, the authors detail the diverse roles of host defence peptides (HDPs) in innate immunity and their association with inflammatory diseases. They highlight the complexity of the immune signalling pathways that are influenced by natural and synthetic HDPs and show that systems biology approaches are important to understand this complexity.

    • Robert E.W. Hancock
    • Evan F. Haney
    • Erin E. Gill
    Review Article
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