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Volume 16 Issue 4, April 2016

'The Enemy Within' by Simon Bradbrook, inspired by the Review on p207.

Research Highlight

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Journal Club

  • Kiyoshi Takeda describes a 2009 paper by Maslowskiet al. that provides the first evidence of a link between microbiota-derived metabolites and human health.

    • Kiyoshi Takeda
    Journal Club
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Research Highlight

  • Nuclear factor-κB signalling induces p62-dependent autophagy of damaged mitochondria to limit NLRP3 inflammasome activation.

    • Kirsty Minton
    Research Highlight
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Review Article

  • A substantial proportion of our genome is composed of endogenous retroelements of viral origin. Such elements can retain viral characteristics and drive activation of the immune system; this can contribute to both undesirable outcomes, such as autoimmune disease, as well as beneficial responses, such as increased immune reactivity to tumours. In this Review, the authors describe the pros and the cons of these 'enemies within'.

    • George Kassiotis
    • Jonathan P. Stoye
    Review Article
  • In this Review, the authors discuss the emerging role of T cell receptor (TCR) specificity and signalling in the differentiation, maintenance and function of regulatory T (TReg) cells. Understanding how TCR signalling regulates TRegcells has important therapeutic implications in the regulation of immune tolerance and inflammation.

    • Ming O. Li
    • Alexander Y. Rudensky
    Review Article
  • The wide diversity of clinical and immunological phenotypes of patients with RAG deficiency, combined with structural characterization of the RAG protein complex, have provided new mechanistic insights into RAG protein function.

    • Luigi D. Notarangelo
    • Min-Sung Kim
    • Yu Nee Lee
    Review Article
  • Autoimmune regulator (AIRE) is best known for its role in immune tolerance. In this Review, the authors summarize the recent advances in our understanding of the diverse functions of AIRE, including its role in selection of regulatory T cells and modulation of non-autoimmune diseases.

    • Mark S. Anderson
    • Maureen A. Su
    Review Article
  • Anecdotal reports of HIV-infected children who have continued to control viral replication after discontinuing antiretroviral therapy have led to the hope that unique factors associated with paediatric infection might offer greater potential for HIV cure in children than in adults.

    • Philip J. Goulder
    • Sharon R. Lewin
    • Ellen M. Leitman
    Review Article
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Correspondence

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