Volume 15 Issue 12, December 2015

Dietary long-chain fatty acids enhance the differentiation of T_H1 and T_H17 cells in the gut, which worsens disease in a mouse model of multiple sclerosis.

B cells expressing GM-CSF activate myeloid cells to drive T cell-mediated multiple sclerosis.

Researchers design switchable therapeutic T cells that can be remotely activated by a small-molecule drug.

Smoking promotes pathogenic T_H17 cell responses by inducing the expression of miR-22 in myeloid cells.

Oestrogen receptor-β promotes immune evasion of endometriotic tissue by blocking TNF-induced apoptosis and enhancing inflammasome activity.

SOCS family member CISH hushes T cell receptor signalling and limits tumour killing.

Ron Germain describes two seminal papers by Marc Jenkins and colleagues that introduced new techniques for analysis of the T cell repertoire.

Inhibition of epigenetic modifiers in ovarian cancer cells blocks cancer progression and improves immunotherapy.

Macrophages populate the body's tissues and organs, where they become highly specialized to preserve organ integrity in the event of microbial invasion or injury. A dynamic crosstalk between the macrophages and their surrounding tissue cells is crucial to ensuring this homeostatic function. This Review highlights the key molecules and mechanisms involved in macrophage–tissue interactions.

This Review describes the role of the immune system in dengue pathogenesis. The authors also discuss new insights gained from human monoclonal antibodies against dengue virus as well as the recent vaccine trials and the challenges to develop an effective dengue vaccine.

Activation of STING (stimulator of interferon genes) by cytosolic aberrant DNA species or cyclic dinucleotides triggers transcription of numerous innate immune genes. In this Review, the author summarizes recent insights into the regulation of STING signalling and its role in autoinflammatory disease and cancer.

This Opinion article proposes that interleukin-15 (IL-15) is a master regulator of tissue-specific T cell responses to promote the destruction of infected cells. Hence, dysregulation of IL-15 production in tissues during sterile inflammation can lead to T cell-mediated autoimmunity.