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Volume 14 Issue 10, October 2014

'Blueprint for the gut' by Simon Bradbrook, inspired by the Review on p667.

Research Highlight

  • Activation of tissue-resident memory CD8+T cells leads to a state of pathogen alert that induces both innate and adaptive immune responses.

    • Elisabeth Kugelberg
    Research Highlight

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In Brief

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Research Highlight

  • Dectin 2 specifically binds the mycobacterial cell wall component mannose-capped lipoarabinomannan.

    • Elisabeth Kugelberg
    Research Highlight
  • FLT3L-activated classical dendritic cells (DCs) drive immune responses following subcutaneous immunization, whereas migratory skin DCs dampen them.

    • Rachel David
    Research Highlight
  • Invariant natural killer T cells can directly limit bacterial dissemination into the joints.

    • Yvonne Bordon
    Research Highlight
  • New vaccine protects monkeys from Ebola virus.

    • Lucy Bird
    Research Highlight
  • Intestinal bacteria stimulate TLR5 on B cells and macrophages to promote antibody responses to subunit vaccination.

    • Kirsty Minton
    Research Highlight
  • The TAM receptors MER and AXL regulate apoptotic cell uptake in diverse immune settings.

    • Yvonne Bordon
    Research Highlight
  • The transcription factor BCL-6 suppresses the expression of a subset of important genes in the glycolytic pathway in transitional effector T cells.

    • Olive Leavy
    Research Highlight
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Review Article

  • Siglecs are sialic acid-binding cell-surface proteins that can help the immune system to distinguish between self and non-self. In this Review, the authors describe how Siglecs can modulate immune cell signalling, outline the role of Siglecs in disease and discuss targeting Siglecs for therapeutic purposes.

    • Matthew S. Macauley
    • Paul R. Crocker
    • James C. Paulson
    Review Article
  • In this Review, the authors describe the unique and varied immune microenvironments that are found along the length of the intestinal tract. They explain how both host-derived and environmental factors shape this regional specialization and discuss the implications for intestinal pathologies, such as inflammatory bowel diseases and cancers.

    • Allan M. Mowat
    • William W. Agace
    Review Article
  • This Review details how the activation of airway epithelial cells and innate immune cells can drive chronic diseases of the lungs, such as asthma and chronic obstructive pulmonary disease. The authors discuss how a better understanding of the mechanisms involved is leading to new treatments for these diseases.

    • Michael J. Holtzman
    • Derek E. Byers
    • Xinyu Wang
    Review Article
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Opinion

  • Reiner and Adams propose a deterministic scenario for diversifying the fates of the cellular progeny of a single antigen-selected lymphocyte, with an element of plasticity based on the nature of the pathogen and the number of responding cells.

    • Steven L. Reiner
    • William C. Adams
    Opinion
  • Studies in mice indicate that targeting antigens to dendritic cells (DCs) can elicit strong CD4+T cell responses. In this Opinion article, the authors summarize the existing DC-targeting approaches; they discuss whether these vaccines are superior to current vaccines and what future studies should entail to successfully introduce these vaccines into a clinical setting.

    • Wolfgang Kastenmüller
    • Kathrin Kastenmüller
    • Robert A. Seder
    Opinion
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Correspondence

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