FIGURE 5 | A model for gene priming with epigenetic marks.

From the following article:

Epigenetics of haematopoietic cell development

Howard Cedar & Yehudit Bergman

Nature Reviews Immunology 11, 478-488 (July 2011)

doi:10.1038/nri2991

Epigenetics of haematopoietic cell development

Bivalent genes are characterized by the presence of trimethylated histone H3 lysine 4 (H3K4me3) and H3K27me3 at their promoters. In haematopoietic stem cells (HSCs), there are two types of bivalent genes with different histone modification patterns. Activatable genes, which are marked with the variant histone H2AZ, H3K2me1, H3K4me1 and H3K9me1, become activated in downstream cells in either the lymphoid or myeloid lineages. By contrast, loci marked with nucleosomes containing H3K9me3 remain silenced in these cells.

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