Table of contents

From the editors

p1 | doi:10.1038/nri2917


Research Highlights

Innate immunity: Calling on the neighbours | PDF (171 KB)

p2 | doi:10.1038/nri2907

Neighbouring intestinal epithelial cells communicate to enhance antibacterial responses.

T cells: Shaping Il4 gene expression | PDF (210 KB)

p3 | doi:10.1038/nri2908

Hypersensitive site 2 (HS2) is essential for GATA3-mediated epigenetic modifications at the Il4 locus.

In brief

Innate immunity | Inflammation | MHC molecules | PDF (125 KB)

p3 | doi:10.1038/nri2914

Viral immunity: Bad memories | PDF (163 KB)

p4 | doi:10.1038/nri2912

Pre-existing antibodies specific for seasonal influenza virus promote severe disease during pandemics.

In brief

Innate immunity | Inflammation | Mucosal immunology | PDF (115 KB)

p4 | doi:10.1038/nri2915

Dendritic cells: pDCs play off scratch | PDF (231 KB)

p5 | doi:10.1038/nri2909

pDCs are an early, transient source of type I IFNs during skin injury and viral infection.

Regulatory T cells: Kings of the delta blues | PDF (426 KB)

p6 | doi:10.1038/nri2905

Regulatory T cell-mediated suppression of γδ T cells prevents spontaneous colitis.

Inflammation: Directions from the matrix | PDF (176 KB)

p6 | doi:10.1038/nri2911

Matrix component biglycan promotes CXCL13 expression to drive B cell-mediated renal inflammation.

Tumour immunology: CD4+ T cells sponsor oncogene addicts | PDF (191 KB)

p7 | doi:10.1038/nri2910

CD4+ T cells mediate the effects of oncogene inactivation on tumour growth and survival.

B cells: Illuminating the dark zone | PDF (245 KB)

p8 | doi:10.1038/nri2906

T cell help is the limiting factor for high-affinity B cell selection in germinal centres.

In the news | PDF (92 KB)

p8 | doi:10.1038/nri2913



Innate immune mechanisms of colitis and colitis-associated colorectal cancer

Maya Saleh & Giorgio Trinchieri

p9 | doi:10.1038/nri2891

Recent evidence indicates that the intestinal microbiota has important functions in maintaining intestinal homeostasis through crosstalk with the innate immune system. However, changes in the intestinal microbiota or breakdown of this crosstalk can result in colitis and colitis-associated colorectal cancer.

Imaging techniques for assaying lymphocyte activation in action

Lakshmi Balagopalan, Eilon Sherman, Valarie A. Barr & Lawrence E. Samelson

p21 | doi:10.1038/nri2903

Increasingly advanced microscopy techniques are now being widely used to gain a better understanding of lymphocyte activation. This Review provides a guide to the latest imaging technologies, highlighting the advantages and limitations that should be considered when choosing which approach to use.

The double life of a B-1 cell: self-reactivity selects for protective effector functions

Nicole Baumgarth

p34 | doi:10.1038/nri2901

In this Review, Nicole Baumgarth describes the development and functions of B-1 cells. These innate-like B cells serve as the major source of natural antibody in mice, and can have important roles in defence against mucosal pathogens and in maintaining tissue homeostasis.

Mechanisms for T cell receptor triggering

P. Anton van der Merwe & Omer Dushek

p47 | doi:10.1038/nri2887

Three main types of mechanism have been proposed to explain T cell receptor (TCR) triggering: aggregation, conformation change and segregation. The most recent data on these mechanisms are discussed here, and the authors propose an integrated model for TCR triggering.



Science and society

Experimental human challenge infections can accelerate clinical malaria vaccine development

Robert W. Sauerwein, Meta Roestenberg & Vasee S. Moorthy

p57 | doi:10.1038/nri2902

These authors put forward their view that the information obtained from experimental human malaria infections justifies the minimal potential risks in well-designed trials and will be essential to the development of an effective malaria vaccine.


The quest for a T cell-based immune correlate of protection against HIV: a story of trials and errors

Richard A. Koup, Barney S. Graham & Daniel C. Douek

p65 | doi:10.1038/nri2890

The lack of natural immunity against HIV has been a major hindrance to the search for immune correlates of protection. Here, the authors propose a new approach for clinical trials of HIV vaccine efficacy that should help to increase our chances of identifying immune correlates of protection.