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Volume 10 Issue 12, December 2010

From The Editors

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Research Highlight

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In Brief

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Research Highlight

  • Fully differentiated monocyte-derived dendritic cells mobilize to lymph nodes in response to lipopolysaccharide.

    • Yvonne Bordon
    Research Highlight
  • Microglial cells derive from primitive haematopoietic progenitors.

    • Olive Leavy
    Research Highlight
  • Mechanism for the induction of endotoxin tolerance in neonatal intestinal epithelial cells.

    • Olive Leavy
    Research Highlight
  • CXCR6 signalling allows natural killer cell persistence in the liver and memory-like responses.

    • Lucy Bird
    Research Highlight
  • The chemokine receptor CX3CR1 promotes effector T cell survival in allergic lungs.

    • Yvonne Bordon
    Research Highlight
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Review Article

  • Our understanding of the triggers and mediators of sterile inflammation has advanced greatly in recent years. Here, Chen and Nuñez provide us with an up-to-date overview of these advances and discuss their therapeutic implications.

    • Grace Y. Chen
    • Gabriel Nuñez
    Review Article
  • Asthma is a complex disease that is typically associated with T helper 2 (TH2)-type inflammation, but it is becoming increasingly clear that other T cell populations can contribute to the disease. Here, the authors describe the functions of distinct T cell subsets in the allergic lung and discuss the implications for future therapies for asthma.

    • Clare M. Lloyd
    • Edith M. Hessel
    Review Article
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Science and Society

  • Children who grow up on traditional farms are protected from developing asthma and allergy. But what are the exact exposures that mediate this protective farm effect, what is the important time period in which these exposures are effective and how do these exposures affect the immune system?

    • Erika von Mutius
    • Donata Vercelli
    Science and Society
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