NPG Library
Below is a selection of recent Research Highlights, Reviews, Research Articles and Commentaries that have been published by Nature Publishing Group journals on the topic of cytokines and cytokine therapies.
Research Highlights
Adding adenosine to the mix
Olive Leavy
doi:10.1038/nri2122
Nature Reviews Immunology 7, 493 (2007)
Regulatory T cells in autoimmunity
Olive Leavy
doi:10.1038/nri2078
Nature Reviews Immunology 7, 322-323 (2007)
Inducing T-cell tolerance in the gut
Elaine Bell
doi:10.1038/nri2029
Nature Reviews Immunology 7, 85 (2007)
News and Views
Seven-year grant offers immune tolerance a boost
Erika Check
doi:10.1038/447125a
Nature 447, 125 (2007)
Foxp3 and Aire in thymus-generated Treg cells: a link in self-tolerance
Takashi Nomura & Shimon Sakaguchi
doi:10.1038/ni0407-333
Nature Immunology 8, 333-334 (2007)
Tolerance and autoimmunity: Entwined pathways lead to immunological tolerance
Ian R van Driel
doi:10.1038/sj.icb.7100059
Immunology and Cell Biology 85, 267-268 (2007)
Giving B cell tolerance the 'TSLiP'
David Allman & Dan Northrup
doi:10.1038/ni0507-481
Nature Immunology 8, 481-483 (2007)
Claudins provide a breath of fresh Aire
Georg A Holländer
doi:10.1038/ni0307-234
Nature Immunology 8, 234-236 (2007)
Regulatory T-cell development: is Foxp3 the decider?
Tyler J Curiel
doi:10.1038/nm0307-250
Nature Medicine 13, 250-253 (2007)
More promiscuity resulting in more tolerance
Dietmar Zehn & Michael J Bevan
doi:10.1038/ni0207-120
Nature Immunology 8, 120-122 (2007)
Skin controls immune regulators
Tomoyuki Yamaguchi & Shimon Sakaguchi
doi:10.1038/nm1206-1358
Nature Medicine 12, 1358-1359 (2006)
Cell cycle 'check points' T cell anergy
Christopher E Rudd
doi:10.1038/ni1106-1130
Nature Immunology 7, 1130-1132 (2006)
Linking diacylglycerol kinase to T cell anergy
Daniel L Mueller
doi:10.1038/ni1106-1132
Nature Immunology 7, 1132-1134 (2006)
Immunology: Protection and privilege
Herman Waldmann
doi:10.1038/nature05165
Nature 442, 987-988 (2006)
Reviews and Perspectives
Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
José A. Villadangos & Petra Schnorrer
doi:10.1038/nri2103
Nature Reviews Immunology 7, 543-555 (2007)
Dendritic cell–regulatory T-cell interactions control self-directed immunity
Christian Lange, Michael Dürr, Hong Doster, Arthur Melms & Felix Bischof
doi:10.1038/sj.icb.7100088
Immunology and Cell Biology advance online publication, 26 June 2007
TGF
signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky
doi:10.1038/nri2095
Nature Reviews Immunology 7, 443-453 (2007)
FOXP3 modifies the phenotypic and functional properties of regulatory T cells
Daniel J. Campbell & Steven F. Ziegler
doi:10.1038/nri2061
Nature Reviews Immunology 7, 305-310 (2007)
Steady-state and inflammatory dendritic-cell development
Ken Shortman & Shalin H. Naik
doi:10.1038/nri1996
Nature Reviews Immunology 7, 19-30 (2006)
Regulation of immune tolerance by anti-inflammatory neuropeptides
Elena Gonzalez-Rey, Alejo Chorny & Mario Delgado
doi:10.1038/nri1984
Nature Reviews Immunology 7, 52-63 (2007)
Articles
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Srinivas Nagaraj, Kapil Gupta, Vladimir Pisarev, Leo Kinarsky, Simon Sherman, Loveleen Kang, Donna L Herber, Jonathan Schneck & Dmitry I Gabrilovich
doi:10.1038/nm1609
Nature Medicine advance online publication, 1 July 2007
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
Ursula Grohmann, Claudia Volpi, Francesca Fallarino, Silvia Bozza, Roberta Bianchi, Carmine Vacca, Ciriana Orabona, Maria L Belladonna, Emira Ayroldi, Giuseppe Nocentini, Louis Boon, Francesco Bistoni, Maria C Fioretti, Luigina Romani, Carlo Riccardi & Paolo Puccetti
doi:10.1038/nm1563
Nature Medicine 13, 579-586 (2007)
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells
Katharina Aschenbrenner, Louise M D'Cruz, Elisabeth H Vollmann, Maria Hinterberger, Jan Emmerich, Lee Kim Swee, Antonius Rolink & Ludger Klein
doi:10.1038/ni1444
Nature Immunology 8, 351-358 (2007)
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation
Thomas Korn, Jayagopala Reddy, Wenda Gao, Estelle Bettelli, Amit Awasthi, Troels R Petersen, B Thomas Bäckström, Raymond A Sobel, Kai W Wucherpfennig, Terry B Strom, Mohamed Oukka & Vijay K Kuchroo
doi:10.1038/nm1564
Nature Medicine 13, 423-431 (2007)
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
Yoko Hamazaki, Harumi Fujita, Takashi Kobayashi, Yongwon Choi, Hamish S Scott, Mitsuru Matsumoto & Nagahiro Minato
doi:10.1038/ni1438
Nature Immunology 8, 304-311 (2007)
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
Masahiro Ono, Hiroko Yaguchi, Naganari Ohkura, Issay Kitabayashi, Yuko Nagamura, Takashi Nomura, Yoshiki Miyachi, Toshihiko Tsukada & Shimon Sakaguchi
doi:10.1038/nature05673
Nature 446, 685-689 (2007)
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Luke M Williams & Alexander Y Rudensky
doi:10.1038/ni1437
Nature Immunology 8, 277-284 (2007)
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
Yisong Y. Wan & Richard A. Flavell
doi:10.1038/nature05479
Nature 445, 766-770 (2007)
Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self
Je-Wook Lee, Mathieu Epardaud, Jing Sun, Jessica E Becker, Alexander C Cheng, Ai-ris Yonekura, Joan K Heath & Shannon J Turley
doi:10.1038/ni1427
Nature Immunology 8, 181-190 (2007)
Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells
Karin Loser, Annette Mehling, Stefanie Loeser, Jenny Apelt, Annegret Kuhn, Stephan Grabbe, Thomas Schwarz, Josef M Penninger & Stefan Beissert
doi:10.1038/nm1518
Nature Medicine 12, 1372-1379 (2007)
Disruption of diacylglycerol metabolism impairs the induction of T cell anergy
Benjamin A Olenchock, Rishu Guo, Jeffery H Carpenter, Martha Jordan, Matthew K Topham, Gary A Koretzky & Xiao-Ping Zhong
doi:10.1038/ni1400
Nature Immunology 7, 1174-1181 (2006)
T cell anergy is reversed by active Ras and is regulated
by diacylglycerol kinase-
Yuanyuan Zha, Reinhard Marks, Allen W Ho, Amy C Peterson, Sujit Janardhan, Ian Brown, Kesavannair Praveen, Stacey Stang, James C Stone & Thomas F Gajewski
doi:10.1038/ni1394
Nature Immunology 7, 1166-1173 (2006)
A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance
Lequn Li, Yoshiko Iwamoto, Alla Berezovskaya & Vassiliki A Boussiotis
doi:10.1038/ni1398
Nature Immunology 7, 1157-1165 (2006)
TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis
Carolyn G King, Takashi Kobayashi, Pedro J Cejas, Taesoo Kim, Kwiyeom Yoon, Gregory K Kim, Elise Chiffoleau, Somia P Hickman, Patrick T Walsh, Laurence A Turka & Yongwon Choi
doi:10.1038/nm1449
Nature Medicine 12, 1088-1092 (2006)
Mast cells are essential intermediaries in regulatory T-cell tolerance
Li-Fan Lu, Evan F. Lind, David C. Gondek, Kathy A. Bennett, Michael W. Gleeson, Karina Pino-Lagos, Zachary A. Scott, Anthony J. Coyle, Jennifer L. Reed, Jacques Van Snick, Terry B. Strom, Xin Xiao Zheng & Randolph J. Noelle
doi:10.1038/nature05010
Nature 442, 997-1002 (2006)
Alloantigen-presenting plasmacytoid dendritic cells mediate tolerance to vascularized grafts
Jordi C Ochando, Chiho Homma, Yu Yang, Andres Hidalgo, Alexandre Garin, Frank Tacke, Veronique Angeli, Yansui Li, Peter Boros, Yaozhong Ding, Rolf Jessberger, Giorgio Trinchieri, Sergio A Lira, Gwendalyn J Randolph & Jonathan S Bromberg
doi:10.1038/ni1333
Nature Immunology 7, 652-662 (2006)
Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+CD25-LAP+ T cells
Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre S Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller, Ruth Maron & Howard L Weiner
doi:10.1038/nm1408
Nature Medicine 12, 627-635 (2006)
Role of thymic- and graft-dependent mechanisms in tolerance induction to rat kidney transplant by donor PBMC infusion
R A Cavinato, F Casiraghi, N Azzollini, M Mister, A Pezzotta, P Cassis, D Cugini, N Perico, G Remuzzi & M Noris
doi:10.1038/sj.ki.5002202
Kidney International 71, 1132-1141 (2007)