NPG Library
Below is a selection of recent Research Highlights, News and Views, Review Articles and Essays that have been published by Nature Publishing Group journals on the topic of mucosal immunology.
Research Highlights
Mucosal immunology: Antimicrobial function for IL-22
Lucy Bird
doi:10.1038/nri2290
Nature Reviews Immunology 8, 163 (2008)
Antibody responses: IgA — peacemaker in the gut
Sharon Ahmad
doi:10.1038/nri2237
Nature Reviews Immunology 8, 6-7 (2008)
Lung inflammation: Disarming neutrophils in cystic fibrosis
Olive Leavy
doi:10.1038/nri2244
Nature Reviews Immunology 8, 8 (2008)
Inflammatory disorders: Chronically amplifying disease
Sarah Crunkhorn
doi:10.1038/nrd2450
Nature Reviews Drug Discovery 6, 868-869 (2007)
Mucosal immunology: Maintaining balance in the gut
Olive Leavy
doi:10.1038/nri2176
Nature Reviews Immunology 7, 750-751 (2007)
Vaccines: Rice-based mucosal vaccine
Marta Tufet
doi:10.1038/nri2135
Nature Reviews Immunology 7, 578-579 (2007)
News and Views
Immunology: Soothing intestinal sugars
Marika C. Kullberg
doi:10.1038/453602a
Nature 453, 602-604 (2008)
Microbiology: The inside story
Asher Mullard
doi:10.1038/453578a
Nature 453, 578-580 (2008)
Microbiology: Straight from the gut
Apoorva Mandavilli
doi:10.1038/453581a
Nature 453, 581-582 (2008)
HIV's gut feeling
Quentin Sattentau
doi:10.1038/ni0308-225
Nature Immunology 9, 225-227 (2008)
Epithelial NF-
B
maintains host gut microflora homeostasis
Yinon Ben-Neriah & Marc Schmidt-Supprian
doi:10.1038/ni0507-479
Nature Immunology 8, 479-481 (2007)
Oral tolerance: Passing CD11b on the way to tolerance
Marc Veldhoen
doi:10.1038/sj.icb.7100106
Immunology and Cell Biology 85, 397-398 (2007)
Bridging efficient viral infection
Thomas J. Hope
doi:10.1038/ncb0307-243
Nature Cell Biology 9, 243-244 (2007)
Reviews
Mucosal delivery of therapeutic and prophylactic molecules using lactic acid bacteria
Jerry M. Wells & Annick Mercenier
doi:10.1038/nrmicro1840
Nature Reviews Microbiology 6, 349-362 (2008)
New therapeutic strategies for treatment of inflammatory bowel disease
R Atreya & M F Neurath
doi:10.1038/mi.2008.7
Mucosal Immunology 1, 175-182 (2008)
Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
Hamida Hammad & Bart N. Lambrecht
doi:10.1038/nri2275
Nature Reviews Immunology 8, 193-204 (2008)
The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
Aras Kadioglu, Jeffrey N. Weiser, James C. Paton & Peter W. Andrew
doi:10.1038/nrmicro1871
Nature Reviews Microbiology 6, 288-301 (2008)
Chlamydia trachomatis infection: host immune responses and potential vaccines
L Hafner, K Beagley & P Timms
doi:10.1038/mi.2007.19
Mucosal Immunology 1, 116-130 (2008)
IL-21 comes of age as a regulator of effector T cells in the gut
M C Fantini, G Monteleone & T T MacDonald
doi:10.1038/mi.2007.17
Mucosal Immunology 1, 110-115 (2008)
Differentiation and homing of IgA-secreting cells
J R Mora & U H von Andrian
doi:10.1038/mi.2007.14
Mucosal Immunology 1, 96-109 (2008)
Regulation of immunological homeostasis in the respiratory tract
Patrick G. Holt, Deborah H. Strickland, Matthew E. Wikström & Frode L. Jahnsen
doi:10.1038/nri2236
Nature Reviews Immunology 8, 142-152 (2008)
Protective immune mechanisms in helminth infection
Robert M. Anthony, Laura I. Rutitzky, Joseph F. Urban, Jr, Miguel J. Stadecker & William C. Gause
doi:10.1038/nri2199
Nature Reviews Immunology 7, 975-987 (2007)
An integrated model of the recognition of Candida albicans by the innate immune system
Mihai G. Netea, Gordon D. Brown, Bart Jan Kullberg & Neil A. R. Gow
doi:10.1038/nrmicro1815
Nature Reviews Microbiology 6, 67-78 (2008)
New links to the pathogenesis of Crohn disease provided by genome-wide association scans
Christopher G. Mathew
doi:10.1038/nrg2203
Nature Reviews Genetics 9, 9-14 (2008)
The immune geography of IgA induction and function
A J Macpherson, K D McCoy, F-E Johansen & P Brandtzaeg
doi:10.1038/mi.2007.6
Mucosal Immunology 1, 11-22 (2008)
HIV infection and the gastrointestinal immune system
J M Brenchley & D C Douek
doi:10.1038/mi.2007.1
Mucosal Immunology 1, 23-30 (2008)
Immune responses to commensal and environmental microbes
Eric G Pamer
doi:10.1038/ni1526
Nature Immunology 8, 1173-1178 (2007)
The Human Microbiome Project
Peter J. Turnbaugh, Ruth E. Ley, Micah Hamady, Claire M. Fraser-Liggett, Rob Knight & Jeffrey I. Gordon
doi:10.1038/nature06244
Nature 449, 804-810 (2007)
Manipulation of host-cell pathways by bacterial pathogens
Amit P. Bhavsar, Julian A. Guttman & B. Brett Finlay
doi:10.1038/nature06247
Nature 449, 827-834 (2007)
Unravelling the pathogenesis of inflammatory bowel disease
R. J. Xavier & D. K. Podolsky
doi:10.1038/nature06005
Nature 448, 427-434 (2007)
Perspectives
Conquering sexually transmitted diseases
Michael N. Starnbach & Nadia R. Roan
doi:10.1038/nri2272
Nature Reviews Immunology 8, 313-317 (2008)
Gut microbiota: a potential new territory for drug targeting
Wei Jia, Houkai Li, Liping Zhao & Jeremy K. Nicholson
doi:10.1038/nrd2505
Nature Reviews Drug Discovery 7, 123-129 (2008)
Vaccination against polio should not be stopped
Konstantin Chumakov, Ellie Ehrenfeld, Eckard Wimmer & Vadim I. Agol
doi:10.1038/nrmicro1769
Nature Reviews Microbiology 5, 952-958 (2007)
Research articles
A microbial symbiosis factor prevents intestinal inflammatory disease
Sarkis K. Mazmanian, June L. Round & Dennis L. Kasper
doi:10.1038/nature07008
Nature453, 620-625 (2008)
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
Sheila A Fisher, Mark Tremelling, Carl A Anderson, Rhian Gwilliam, Suzannah Bumpstead, Natalie J Prescott, Elaine R Nimmo, Dunecan Massey, Carlo Berzuini, Christopher Johnson, Jeffrey C Barrett, Fraser R Cummings, Hazel Drummond, Charlie W Lees, Clive M Onnie, Catherine E Hanson, Katarzyna Blaszczyk, Mike Inouye, Philip Ewels, Radhi Ravindrarajah, Andrew Keniry, Sarah Hunt, Martyn Carter, Nick Watkins, Willem Ouwehand, Cathryn M Lewis, Lon Cardon, the Wellcome Trust Case Control Consortium, Alan Lobo, Alastair Forbes, Jeremy Sanderson, Derek P Jewell, John C Mansfield, Panos Deloukas, Christopher G Mathew, Miles Parkes & Jack Satsangi
doi:10.1038/ng.145
Nature Genetics
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
Andre Franke, Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak & Stefan Schreiber
doi:10.1038/ng.148
Nature Genetics
Mechanism of NKT cell activation by intranasal coadministration
of 
-galactosylceramide,
which can induce cross-protection against influenza viruses
H Kamijuku, Y Nagata, X Jiang, T Ichinohe, T Tashiro, K Mori, M Taniguchi, K Hase, H Ohno, T Shimaoka, S Yonehara, T Odagiri, M Tashiro, T Sata, H Hasegawa & K-i Seino
doi:10.1038/mi.2008.2
Mucosal Immunology 1, 208-218 (2008)
ROR
t
is dispensable for the development of intestinal mucosal T cells
T Naito, T Shiohara, T Hibi, M Suematsu & H Ishikawa
doi:10.1038/mi.2008.4
Mucosal Immunology 1, 198-207 (2008)
Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut
Manuela Raffatellu, Renato L Santos, David E Verhoeven, Michael D George, R Paul Wilson, Sebastian E Winter, Ivan Godinez, Sumathi Sankaran, Tatiane A Paixao, Melita A Gordon, Jay K Kolls, Satya Dandekar & Andreas J Bäumler
doi:10.1038/nm1743
Nature Medicine 14, 421-428 (2008)
Newly identified genetic risk variants for celiac disease related to the immune response
Karen A Hunt, Alexandra Zhernakova, Graham Turner, Graham A R Heap, Lude Franke, Marcel Bruinenberg, Jihane Romanos, Lotte C Dinesen, Anthony W Ryan, Davinder Panesar, Rhian Gwilliam, Fumihiko Takeuchi, William M McLaren, Geoffrey K T Holmes, Peter D Howdle, Julian R F Walters, David S Sanders, Raymond J Playford, Gosia Trynka, Chris J J Mulder, M Luisa Mearin, Wieke H M Verbeek, Valerie Trimble, Fiona M Stevens, Colm O'Morain, Nicholas P Kennedy, Dermot Kelleher, Daniel J Pennington, David P Strachan, Wendy L McArdle, Charles A Mein, Martin C Wapenaar, Panos Deloukas, Ralph McGinnis, Ross McManus, Cisca Wijmenga & David A van Heel
doi:10.1038/ng.102
Nature Genetics 40, 395-402 (2008)
Gene-centric association mapping of chromosome 3p implicates MST1 in IBD pathogenesis
P Goyette, C Lefebvre, A Ng, S R Brant, J H Cho, R H Duerr, M S Silverberg, K D Taylor, A Latiano, G Aumais, C Deslandres, G Jobin, V Annese, M J Daly, R J Xavier & J D Rioux
doi:10.1038/mi.2007.15
Mucosal Immunology 1, 131-138 (2008)
IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia
Shean J Aujla, Yvonne R Chan, Mingquan Zheng, Mingjian Fei, David J Askew, Derek A Pociask, Todd A Reinhart, Florencia McAllister, Jennifer Edeal, Kristi Gaus, Shahid Husain, James L Kreindler, Patricia J Dubin, Joseph M Pilewski, Mike M Myerburg, Carol A Mason, Yoichiro Iwakura & Jay K Kolls
doi:10.1038/nm1710
Nature Medicine 14, 275-281 (2008)
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
Yan Zheng, Patricia A Valdez, Dimitry M Danilenko, Yan Hu, Susan M Sa, Qian Gong, Alexander R Abbas, Zora Modrusan, Nico Ghilardi, Frederic J de Sauvage & Wenjun Ouyang
doi:10.1038/nm1720
Nature Medicine 14, 282-289 (2008)
HIV-1 envelope protein binds to and signals through
integrin 4
7,
the gut mucosal homing receptor for peripheral T cells
James Arthos, Claudia Cicala, Elena Martinelli, Katilyn Macleod, Donald Van Ryk, Danlan Wei, Zhen Xiao, Timothy D Veenstra, Thomas P Conrad, Richard A Lempicki, Sherry McLaughlin, Massimiliano Pascuccio, Ravindra Gopaul, Jonathan McNally, Catherine C Cruz, Nina Censoplano, Eva Chung, Kristin N Reitano, Shyam Kottilil, Diana J Goode & Anthony S Fauci
doi:10.1038/ni1566
Nature Immunology 9, 301-309 (2008)
Cholera toxin, E. coli heat-labile toxin, and non-toxic derivatives induce dendritic cell migration into the follicle-associated epithelium of Peyer's patches
N G Anosova, S Chabot, V Shreedhar, J A Borawski, B L Dickinson & M R Neutra
doi:10.1038/mi.2007.7
Mucosal Immunology 1, 59-67 (2007)
Retinoic acid receptor signaling levels and antigen dose regulate gut homing receptor expression on CD8+ T cells
M Svensson, B Johansson-Lindbom, F Zapata, E Jaensson, L M Austenaa, R Blomhoff & W W Agace
doi:10.1038/mi.2007.4
Mucosal Immunology 1, 38-48 (2008)
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses
Timothy L Denning, Yi-chong Wang, Seema R Patel, Ifor R Williams & Bali Pulendran
doi:10.1038/ni1511
Nature Immunology 8, 1086-1094 (2007)
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells
Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira & Toshiaki Ohteki
doi:10.1038/nature06033
Nature 448, 929-933 (2007)
Loss of integrin v8
on dendritic cells causes autoimmunity and colitis in mice
Mark A. Travis, Boris Reizis, Andrew C. Melton, Emma Masteller, Qizhi Tang, John M. Proctor, Yanli Wang, Xin Bernstein, Xiaozhu Huang, Louis F. Reichardt, Jeffrey A. Bluestone & Dean Sheppard
doi:10.1038/nature06110
Nature 449, 361-365 (2007)
The correlation between proinflammatory cytokines, MAdCAM-1
and cellular infiltration in the inflamed colon from TNF-
gene knockout mice
Yinghua Xu, Nicholas H Hunt & Shisan Bao
doi:10.1038/sj.icb.7100112
Immunology and Cell Biology 85, 633-639 (2007)
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
David A van Heel, Lude Franke, Karen A Hunt, Rhian Gwilliam, Alexandra Zhernakova, Mike Inouye, Martin C Wapenaar, Martin C N M Barnardo, Graeme Bethel, Geoffrey K T Holmes, Con Feighery, Derek Jewell, Dermot Kelleher, Parveen Kumar, Simon Travis, Julian RF Walters, David S Sanders, Peter Howdle, Jill Swift, Raymond J Playford, William M McLaren, M Luisa Mearin, Chris J Mulder, Ross McManus, Ralph McGinnis, Lon R Cardon, Panos Deloukas & Cisca Wijmenga
doi:10.1038/ng2058
Nature Genetics 39, 827-829 (2007)
Epithelial NEMO links innate immunity to chronic intestinal inflammation
Arianna Nenci, Christoph Becker, Andy Wullaert, Ralph Gareus, Geert van Loo, Silvio Danese, Marion Huth, Alexei Nikolaev, Clemens Neufert, Blair Madison, Deborah Gumucio, Markus F. Neurath & Manolis Pasparakis
doi:10.1038/nature05698
Nature 446, 557-561 (2007)
Epithelial-cell-intrinsic IKK-
expression regulates intestinal immune homeostasis
Colby Zaph, Amy E. Troy, Betsy C. Taylor, Lisa D. Berman-Booty, Katherine J. Guild, Yurong Du, Evan A. Yost, Achim D. Gruber, Michael J. May, Florian R. Greten, Lars Eckmann, Michael Karin & David Artis
doi:10.1038/nature05590
Nature 446, 552-556 (2007)
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
John D Rioux, Ramnik J Xavier, Kent D Taylor, Mark S Silverberg, Philippe Goyette, Alan Huett, Todd Green, Petric Kuballa, M Michael Barmada, Lisa Wu Datta, Yin Yao Shugart, Anne M Griffiths, Stephan R Targan, Andrew F Ippoliti, Edmond-Jean Bernard, Ling Mei, Dan L Nicolae, Miguel Regueiro, L Philip Schumm, A Hillary Steinhart, Jerome I Rotter, Richard H Duerr, Judy H Cho, Mark J Daly & Steven R Brant
doi:10.1038/ng2032
Nature Genetics 39, 596-604 (2007)
Langerin is a natural barrier to HIV-1 transmission by Langerhans cells
Lot de Witte, Alexey Nabatov, Marjorie Pion, Donna Fluitsma, Marein A W P de Jong, Tanja de Gruijl, Vincent Piguet, Yvette van Kooyk & Teunis B H Geijtenbeek
doi:10.1038/nm1541
Nature Medicine 13, 367-371 (2007)
Epithelial cells trigger frontline immunoglobulin class switching through a pathway regulated by the inhibitor SLPI
Weifeng Xu, Bing He, April Chiu, Amy Chadburn, Meimei Shan, Malwina Buldys, Aihao Ding, Daniel M Knowles, Paul A Santini & Andrea Cerutti
doi:10.1038/ni1434
Nature Immunology 8, 294-303 (2007)
