NPG Library
Below is a selection of recent Research Highlights, Reviews, Research Articles and Commentaries that have been published by Nature Publishing Group journals on the topic of cytokines and cytokine therapies.
Research Highlights
TSLP and B-cell homeostasis
Elaine Bell
doi:10.1038/nri2080
Nature Reviews Immunology 7, 322-323 (2007)
Self-control by TH1 cells
Olive Leavy
doi:10.1038/nri2043
Nature Reviews Immunology 7, 171 (2007)
TH17 cells are a potential therapeutic target in autoimmune arthritis
doi:10.1038/ncprheum0396
Nature Clinical Practice Rheumatology 3, 69 (2007)
Th17 cells: An orphan with influence
Brigitta Stockinger
doi:10.1038/sj.icb.7100035
Immunology and Cell Biology 85, 83-84 (2007)
Viral persistence: IL-10 is the key
Susan Jones
doi:10.1038/nri1989
Nature Reviews Immunology 6, 878-879 (2006)
Unlocking TH17-cell differentiation
Sharon Ahmad
doi:10.1038/nri1963
Nature Reviews Immunology 6, 793 (2006)
IL-25 expels worms
Karen Honey
doi:10.1038/nri1874
Nature Reviews Immunology 6, 431 (2006)
News and Views
Act1-ivating IL-17 inflammation
Christopher A Hunter
doi:10.1038/ni0307-232
Nature Immunology 8, 232-234 (2007)
IL-23: a master regulator in Crohn disease
Markus F Neurath
doi:10.1038/nm0107-26
Nature Medicine 13, 26-28 (2007)
IL-7 and the thymus dictate the NK cell 'labor market'
Mark J Smyth & Stephen L Nutt
doi:10.1038/ni1106-1134
Nature Immunology 7, 1134-1136 (2006)
All in the family: IL-27 suppression of TH-17 cells
John Colgan & Paul Rothman
doi:10.1038/ni0906-899
Nature Immunology 7, 899-901 (2006)
IL-2 gets with the program
Stephen P Schoenberger & Edith M Janssen
doi:10.1038/ni0806-798
Nature Immunology 7, 798-800 (2006)
TGF-
,
a 'double agent' in the immune pathology war
Daniel J Cua & Robert A Kastelein
doi:10.1038/ni0606-557
Nature Immunology 7, 557-559 (2006)
Immunology: What does it mean to be just 17?
Cristina M. Tato & John J. O'Shea
doi:10.1038/441166a
Nature 441, 166-168 (2006)
Reviews and Perspectives
TH-17 cells in the circle of immunity and autoimmunity
Estelle Bettelli, Mohamed Oukka & Vijay K Kuchroo
doi:10.1038/ni0407-345
Nature Immunology 8, 345-350 (2007)
Cooperation of Toll-like receptor signals in innate immune defence
Giorgio Trinchieri & Alan Sher
doi:10.1038/nri2038
Nature Reviews Immunology 7, 179-190 (2007)
Suppression of TH2-type allergic reactions by helminth infection
Padraic G. Fallon & Niamh E. Mangan
doi:10.1038/nri2039
Nature Reviews Immunology 7, 220-230 (2007)
Interleukin-7 receptor expression: intelligent design
Renata Mazzucchelli & Scott K. Durum
doi:10.1038/nri2023
Nature Reviews Immunology 7, 144-154 (2007)
A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell–mediated tissue damage
Lawrence Steinman
doi:10.1038/nm1551
Nature Medicine 13, 139-145 (2007)
The regulatory role of TGF-
in airway remodeling in asthma
Toluwalope Makinde, Richard F Murphy & Devendra K Agrawal
doi:10.1038/sj.icb.7100044
Immunology and Cell Biology advance online publication, 27 February 2007
Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment
Hua Yu, Marcin Kortylewski & Drew Pardoll
doi:10.1038/nri1995
Nature Reviews Immunology 7, 41-51 (2007)
Cytokine regulation of immunopathology in toxoplasmosis
Pamela J Gaddi & George S Yap
doi:10.1038/sj.icb.7100038
Immunology and Cell Biology 85, 155-159 (2007)
Biologic therapies in rheumatology: lessons learned, future directions
Vibeke Strand, Robert Kimberly & John D. Isaacs
doi:10.1038/nrd2196
Nature Reviews Drug Discovery 6, 75-92 (2007)
Interleukin 6: from bench to bedside
Norihiro Nishimoto & Tadamitsu Kishimoto
doi:10.1038/ncprheum0338
Nature Clinical Practice Rheumatology 2, 619-626 (2006)
Interferons, immunity and cancer immunoediting
Gavin P. Dunn, Catherine M. Koebel & Robert D. Schreiber
doi:10.1038/nri1961
Nature Reviews Immunology 6, 836-848 (2006)
MIF: a new cytokine link between rheumatoid arthritis and atherosclerosis
Eric F. Morand, Michelle Leech & Jürgen Bernhagen
doi:10.1038/nrd2029
Nature Reviews Drug Discovery 5, 399-411 (2006)
Research articles
Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development
Alexander Astrakhan, Miyuki Omori, Thuc Nguyen, Shirly Becker-Herman, Masanori Iseki, Theingi Aye, Kelly Hudkins, James Dooley, Andrew Farr, Charles E Alpers, Steven F Ziegler & David J Rawlings
doi:10.1038/ni1452
Nature Immunology 8, 522-531 (2007)
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
Salomé LeibundGut-Landmann, Olaf Gro
,
Matthew J Robinson, Fabiola Osorio, Emma C Slack, S Vicky Tsoni, Edina
Schweighoffer, Victor Tybulewicz, Gordon D Brown, Jürgen Ruland
& Caetano Reis e Sousa
doi:10.1038/ni1460
Nature Immunology advance online publication, 22 April 2007
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge
Shabaana A Khader, Guy K Bell, John E Pearl, Jeffrey J Fountain, Javier Rangel-Moreno, Garth E Cilley, Fang Shen, Sheri M Eaton, Sarah L Gaffen, Susan L Swain, Richard M Locksley, Laura Haynes, Troy D Randall & Andrea M Cooper
doi:10.1038/ni1449
Nature Immunology 8, 369-377 (2007)
IFN-
mediates CD4+ T-cell loss and impairs secondary antitumor
responses after successful initial immunotherapy
Vanessa Berner, Haiyan Liu, Qing Zhou, Kory L Alderson, Kai Sun, Jonathan M Weiss, Timothy C Back, Dan L Longo, Bruce R Blazar, Robert H Wiltrout, Lisbeth A Welniak, Doug Redelman & William J Murphy
doi:10.1038/nm1554
Nature Medicine 13, 354-360 (2007)
The adaptor Act1 is required for interleukin 17–dependent signaling associated with autoimmune and inflammatory disease
Youcun Qian, Caini Liu, Justin Hartupee, Cengiz Zubeyir Altuntas, Muhammet Fatih Gulen, Daniel Jane-wit, Jianhua Xiao, Yi Lu, Natalia Giltiay, Jinbo Liu, Tomasz Kordula, Qi-Wei Zhang, Bruce Vallance, Shadi Swaidani, Mark Aronica, Vincent K Tuohy, Thomas Hamilton & Xiaoxia Li
doi:10.1038/ni1439
Nature Immunology 8, 247-256 (2007)
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells
Ivana M Djuretic, Ditsa Levanon, Varda Negreanu, Yoram Groner, Anjana Rao & K Mark Ansel
doi:10.1038/ni1424
Nature Immunology 8, 145-153 (2007)
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
Yan Zheng, Dimitry M. Danilenko, Patricia Valdez, Ian Kasman, Jeffrey Eastham-Anderson, Jianfeng Wu & Wenjun Ouyang
doi:10.1038/nature05505
Nature 445, 648-651 (2006)
Signals mediated by transforming growth factor-
initiate autoimmune encephalomyelitis, but chronic inflammation is
needed to sustain disease
Marc Veldhoen, Richard J Hocking, Richard A Flavell & Brigitta Stockinger
doi:10.1038/ni1391
Nature Immunology 7, 1151-1156 (2006)
Interleukin-10 determines viral clearance or persistence in vivo
David G Brooks, Matthew J Trifilo, Kurt H Edelmann, Luc Teyton, Dorian B McGavern & Michael B A Oldstone
doi:10.1038/nm1492
Nature Medicine 7, 1301-1309 (2006)
Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells
Marcel Batten, Ji Li, Sothy Yi, Noelyn M Kljavin, Dimitry M Danilenko, Sophie Lucas, James Lee, Frederic J de Sauvage & Nico Ghilardi
doi:10.1038/ni1375
Nature Immunology 7, 929-936 (2006)
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
Jason S Stumhofer, Arian Laurence, Emma H Wilson, Elaine Huang, Cristina M Tato, Leanne M Johnson, Alejandro V Villarino, Qiulong Huang, Akihiko Yoshimura, David Sehy, Christiaan J M Saris, John J O'Shea, Lothar Hennighausen, Matthias Ernst & Christopher A Hunter
doi:10.1038/ni1376
Nature Immunology 7, 937-945 (2006)
Interleukin 18–independent engagement of interleukin
18 receptor-
is required for autoimmune inflammation
Ilona Gutcher, Eduard Urich, Karina Wolter, Marco Prinz & Burkhard Becher
doi:10.1038/ni1377
Nature Immunology 7, 946-953 (2006)
Interleukin-2 signals during priming are required for secondary expansion of CD8+ memory T cells
Matthew A. Williams, Aaron J. Tyznik & Michael J. Bevan
doi:10.1038/nature04790
Nature 441, 890-893 (2006)
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
Estelle Bettelli, Yijun Carrier, Wenda Gao, Thomas Korn, Terry B. Strom, Mohamed Oukka, Howard L. Weiner & Vijay K. Kuchroo
doi:10.1038/nature04753
Nature 441, 235-238 (2006)
Transforming growth factor-
induces development of the TH17 lineage
Paul R. Mangan, Laurie E. Harrington, Darrell B. O'Quinn, Whitney S. Helms, Daniel C. Bullard, Charles O. Elson, Robin D. Hatton, Sharon M. Wahl, Trenton R. Schoeb & Casey T. Weaver
doi:10.1038/nature04754
Nature 441, 231-234 (2006)
