Cytokines act as key communicators for immune cells and maintaining a delicate balance in the level of these communicators is vital for health
— in many chronic diseases, this balance is disrupted. Thus, therapeutic targeting of cytokine pathways promises great hope for patients suffering from chronic diseases such as rheumatoid arthritis. This Focus highlights the latest advances in cytokine research and the application of these findings for clinical intervention.
Foreword
Cytokines and interventional immunology
David A. Hafler
doi:10.1038/nri2101
Nature Reviews Immununology 7, 423 (2007)
Research Highlights
T cells: Human TH17 cells take centre stage
Lucy Bird
doi:10.1038/nri2108
Nature Reviews Immunology 7, 413 (2007)
Asthma and allergy: Opposing roles for osteopontin
Lucy Bird
doi:10.1038/nri2109
Nature Reviews Immunology 7, 417 (2007)
In Brief
doi:10.1038/nri2113
Nature Reviews Immunology 7, 419 (2007)
Progress Article
TH1 cells control themselves by producing interleukin-10
Anne O'Garra & Paulo Vieira
doi:10.1038/nri2097
Nature Reviews Immunology 7, 425-428 (2007)
Review Articles
Cytokines in the pathogenesis of rheumatoid arthritis
Iain B. McInnes & Georg Schett
doi:10.1038/nri2094
Nature Reviews Immunology 7, 429-442 (2007)
TGFβ signalling in control of T-cell-mediated self-reactivity
Yuri P Rubtsov & Alexander Y Rudensky
doi:10.1038/nri2095
Nature Reviews Cancer 7, 443-453 (2007)
SOCS proteins, cytokine signalling and immune regulation
Akihiko Yoshimura, Tetsuji Naka & Masato Kubo
doi:10.1038/nri2093
Nature Reviews Immunology 7, 454-465 (2007)
