Simon Bradbrook

USE THE FORCE

How mechanical forces regulate leukocytes

Latest Reviews

  • Review |

    This Review describes recent advances in our understanding of the ontogeny, development and function of brain-resident macrophages and microglia, including their normal functions during brain development and homeostasis and how disturbance of these functions may precipitate neurodegenerative and neuropsychiatric diseases.

    • Qingyun Li
    •  & Ben A. Barres
  • Review |

    In this Review, the authors detail the complex expression patterns and regulation of programmed cell death protein 1 (PD1) and its ligands. The authors focus on the importance of understanding these pathways in order to optimize the efficiency and safety of immune checkpoint blockade in patients.

    • Arlene H. Sharpe
    •  & Kristen E. Pauken
  • Opinion |

    In this Opinion article, the authors consider how poverty and diet can shape the microbiota and immune health. They highlight how this contributes to the greater levels of chronic disease that are experienced by low-income individuals in high-income societies.

    • Christy A. Harrison
    •  & Douglas Taren
  • Review |

    This Review describes our current understanding of the mechanisms regulating T helper 2 (TH2) cell development and function. The authors discuss how our increasing comprehension of these pathways is leading to the development of novel therapies for TH2 cell-mediated diseases, such as asthma and allergy.

    • Jennifer A. Walker
    •  & Andrew N. J. McKenzie
  • Review |

    Antibodies play an essential role in host defence against pathogens by binding to microorganisms and infected cells and exerting various effector functions. In this Review, Lu and colleagues summarize antibody isotypes and subclasses, modifications, receptor binding and signalling and effector functions in the context of infectious diseases.

    • Lenette L. Lu
    • , Todd J. Suscovich
    • , Sarah M. Fortune
    •  & Galit Alter
  • Review |

    The hygiene hypothesis postulates that an increased frequency of infections contributes to a decrease in autoimmune and allergic diseases. Here, Bach summarizes the epidemiological and experimental evidence supporting this hypothesis and discusses the importance of innate immune receptors in mediating the protective effect of pathogens and commensals on autoimmunity.

    • Jean-François Bach

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