FIGURE 2 | The organization of the ENS of human and medium–large mammals.

From the following article:

The enteric nervous system and neurogastroenterology

John B. Furness

Nature Reviews Gastroenterology & Hepatology 9, 286-294 (May 2012)

doi:10.1038/nrgastro.2012.32

The enteric nervous system and neurogastroenterology

The ENS has ganglionated plexuses, the myenteric plexus between the longitudinal and circular layers of the external musculature and the SMP that has outer and inner components. Nerve fiber bundles connect the ganglia and also form plexuses that innervate the longitudinal muscle, circular muscle, muscularis mucosae, intrinsic arteries and the mucosa. Innervation of gastroenteropancreatic endocrine cells and gut-associated lymphoid tissue is also present, which is not illustrated here. Abbreviations: ENS, enteric nervous system; SMP, submucosal plexus. Modified with permission from Furness, J. B. The Enteric Nervous System (Blackwell, Oxford, 2006).

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