Table of contents

March 2009 Volume 6 No 3



A perfect storm

Stephen B Hanauer


doi:10.1038/ncpgasthep1381 | Full Text | PDF (435K)


Research Highlights

Finnish public health colorectal cancer screening program justifies continuation


doi:10.1038/ncpgasthep1342 | Full Text | PDF (448K)

Fecal calprotectin: a useful diagnostic marker for acute, bacterial diarrhea


doi:10.1038/ncpgasthep1343 | Full Text | PDF (448K)

Improved diagnostic accuracy of wireless esophageal pH monitoring


doi:10.1038/ncpgasthep1344 | Full Text | PDF (458K)

Similar risk of lower gastrointestinal events with etoricoxib and diclofenac


doi:10.1038/ncpgasthep1346 | Full Text | PDF (458K)

Adalimumab maintenance therapy improves quality of life in patients with Crohn's disease


doi:10.1038/ncpgasthep1350 | Full Text | PDF (451K)

Pretreatment algorithm predicts response to HCV antiviral therapy


doi:10.1038/ncpgasthep1345 | Full Text | PDF (451K)

Sex-related disparities still exist in liver transplant allocation


doi:10.1038/ncpgasthep1347 | Full Text | PDF (451K)

A reliable DNA microarray approach for identification of bacterial stool pathogens


doi:10.1038/ncpgasthep1348 | Full Text | PDF (457K)

Administration of physiologic plasma lipid reduces food intake in rats and mice


doi:10.1038/ncpgasthep1349 | Full Text | PDF (447K)


Practice Points

Feasibility of combined EUS–FNA and ERCP for obstructive jaundice from presumed pancreatic malignancy

Shajan Peter and Mohamad A Eloubeidi


doi:10.1038/ncpgasthep1365 | Full Text | PDF (459K)

Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?

Markus F Neurath and Ralf Kiesslich


doi:10.1038/ncpgasthep1355 | Full Text | PDF (462K)

Is weight loss more successful after gastric bypass than gastric banding for obese patients?

Paul O'Brien


doi:10.1038/ncpgasthep1363 | Full Text | PDF (458K)

High-dose versus standard-dose PPI in triple therapy for Helicobacter pylori eradication

Mitsushige Sugimoto and David Y Graham


doi:10.1038/ncpgasthep1353 | Full Text | PDF (468K)

Which fecal occult blood test is best to screen for colorectal cancer?

Graeme P Young and Stephen R Cole


doi:10.1038/ncpgasthep1358 | Full Text | PDF (459K)

Combining two imaging techniques is best to diagnose small-bowel Crohn's disease

Giovanni Maconi and Gabriele Bianchi Porro


doi:10.1038/ncpgasthep1354 | Full Text | PDF (459K)

Crohn's colitis versus ulcerative colitis: should surveillance for dysplasia and cancer differ?

Burton I Korelitz


doi:10.1038/ncpgasthep1362 | Full Text | PDF (459K)



What is the optimal duration of stent placement for refractory, benign esophageal strictures?

Peter D Siersema and Meike MC Hirdes


The optimal duration for stent placement in patients with refractory, benign esophageal strictures (RBES) is not clear. This Viewpoint article discusses the types of stent available for RBES, their benefits and limitations, and the factors that influence stenting duration. The authors provide their opinion regarding optimal stent choice and duration on the basis of available evidence and their own experience.

doi:10.1038/ncpgasthep1364 | Full Text | PDF (460K)

Behavioral therapy for IBS

Peter J Whorwell


IBS is a major drain on health-care resources, partly because the pharmacological management of this condition is currently unsatisfactory. Cognitive behavioral therapy, psychotherapy and hypnotherapy can help by providing a global therapeutic approach for IBS. This Viewpoint article discusses the available evidence for these behavioral therapies and highlights the benefits and the difficulties of using such approaches.

doi:10.1038/ncpgasthep1361 | Full Text | PDF (458K)



Pathogenesis of portal hypertensive gastropathy: translating basic research into clinical practice

Rafael F Perini, Paula RS Camara and Jose GP Ferraz


Portal hypertensive gastropathy (PHG) is often seen in patients with portal hypertension, and can lead to transfusion-dependent anemia as well as acute, life-threatening bleeding episodes. This Review article discusses the available knowledge regarding the mechanisms underlying the pathogenesis of PHG that provide reasonable grounds for the treatment of this condition, ultimately translating basic research into clinical practice.

doi:10.1038/ncpgasthep1356 | Full Text | PDF (674K)

Multimodal approaches to the treatment of hepatocellular carcinoma

Giuseppe Cabibbo, Federica Latteri, Michela Antonucci and Antonio Craxì


The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide. Despite the use of aggressive treatments, the survival of patients with HCC is affected by tumor recurrence and the development of extrahepatic metastases. This Review discusses the available evidence for specific multimodal approaches in the treatment of HCC. Future directions of combinatory treatment approaches are also discussed.

doi:10.1038/ncpgasthep1357 | Full Text | PDF (553K)

Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers

Ken Herrmann, Axel Walch, Benjamin Balluff, Marc Tänzer, Heinz Höfler, Bernd J Krause, Markus Schwaiger, Helmut Friess, Roland M Schmid and Matthias PA Ebert


The development of multimodality and targeted treatment strategies has improved the prognosis of patients with gastrointestinal cancers. Not all patients, however, benefit equally from these treatment approaches, and the ability to predict who will respond positively to a treatment type is of particular importance. This Review discusses the role of biomarkers and metabolic imaging approaches in the prediction of response to therapy early on in treatment.

doi:10.1038/ncpgasthep1366 | Full Text | PDF (896K)


Case Study

Continuing Medical Education

A case of Cowden's syndrome presenting with gastric carcinomas and gastrointestinal polyposis

Khalid Al-Thihli, Laura Palma, Victoria Marcus, Matthew Cesari, Yael B Kushner, Alan Barkun and William D Foulkes


This article considers the case of a 73-year-old white man who presented with synchronous gastric carcinomas and a 20-year history of mixed polyposis. Genetic-testing and molecular-pathology analyses confirmed a diagnosis of Cowden's syndrome. The case explores the diagnostic challenges of differentiating between hamartomatous and adenomatous polyposis syndromes in patients with mixed polyposis, and emphasizes the need to characterize the risk of gastrointestinal cancer in patients with this syndrome.

doi:10.1038/ncpgasthep1359 | Full Text | PDF (770K)


Article Responses

Duration of treatment with albendazole for hepatic toxocariasis

Masahide Yoshikawa


doi:10.1038/ncpgasthep1367 | Full Text

Probiotic prophylaxis in acute pancreatitis: prudence required

Marc GH Besselink, Hjalmar C van Santvoort, Marja A Boermeester, Erik Buskens, Louis MA Akkermans and Hein G Gooszen


doi:10.1038/ncpgasthep1368 | Full Text

Misconception of treatment for liver disease unique to pregnancy

Weekitt Kittisupamongkol


doi:10.1038/ncpgasthep1369 | Full Text

Gastric electric stimulation is a viable option in gastroparesis treatment

Thomas L Abell


doi:10.1038/ncpgasthep1370 | Full Text

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