A perfect storm

Stephen B Hanauer

doi:10.1038/ncpgasthep1381 | Full Text | PDF (435K)

Finnish public health colorectal cancer screening program justifies continuation

doi:10.1038/ncpgasthep1342 | Full Text | PDF (448K)

Fecal calprotectin: a useful diagnostic marker for acute, bacterial diarrhea

doi:10.1038/ncpgasthep1343 | Full Text | PDF (448K)

Improved diagnostic accuracy of wireless esophageal pH monitoring

doi:10.1038/ncpgasthep1344 | Full Text | PDF (458K)

Similar risk of lower gastrointestinal events with etoricoxib and diclofenac

doi:10.1038/ncpgasthep1346 | Full Text | PDF (458K)

Adalimumab maintenance therapy improves quality of life in patients with Crohn's disease

doi:10.1038/ncpgasthep1350 | Full Text | PDF (451K)

Pretreatment algorithm predicts response to HCV antiviral therapy

doi:10.1038/ncpgasthep1345 | Full Text | PDF (451K)

Sex-related disparities still exist in liver transplant allocation

doi:10.1038/ncpgasthep1347 | Full Text | PDF (451K)

A reliable DNA microarray approach for identification of bacterial stool pathogens

doi:10.1038/ncpgasthep1348 | Full Text | PDF (457K)

Administration of physiologic plasma lipid reduces food intake in rats and mice

doi:10.1038/ncpgasthep1349 | Full Text | PDF (447K)

Feasibility of combined EUS–FNA and ERCP for obstructive jaundice from presumed pancreatic malignancy

Shajan Peter and Mohamad A Eloubeidi

doi:10.1038/ncpgasthep1365 | Full Text | PDF (459K)

Is chromoendoscopy the new standard for cancer surveillance in patients with ulcerative colitis?

Markus F Neurath and Ralf Kiesslich

doi:10.1038/ncpgasthep1355 | Full Text | PDF (462K)

High-dose versus standard-dose PPI in triple therapy for Helicobacter pylori eradication

Mitsushige Sugimoto and David Y Graham

doi:10.1038/ncpgasthep1353 | Full Text | PDF (468K)

Which fecal occult blood test is best to screen for colorectal cancer?

Graeme P Young and Stephen R Cole

doi:10.1038/ncpgasthep1358 | Full Text | PDF (459K)

Combining two imaging techniques is best to diagnose small-bowel Crohn's disease

Giovanni Maconi and Gabriele Bianchi Porro

doi:10.1038/ncpgasthep1354 | Full Text | PDF (459K)

Crohn's colitis versus ulcerative colitis: should surveillance for dysplasia and cancer differ?

Burton I Korelitz

doi:10.1038/ncpgasthep1362 | Full Text | PDF (459K)

What is the optimal duration of stent placement for refractory, benign esophageal strictures?

Peter D Siersema and Meike MC Hirdes

The optimal duration for stent placement in patients with refractory, benign esophageal strictures (RBES) is not clear. This Viewpoint article discusses the types of stent available for RBES, their benefits and limitations, and the factors that influence stenting duration. The authors provide their opinion regarding optimal stent choice and duration on the basis of available evidence and their own experience.

doi:10.1038/ncpgasthep1364 | Full Text | PDF (460K)

Behavioral therapy for IBS

Peter J Whorwell

IBS is a major drain on health-care resources, partly because the pharmacological management of this condition is currently unsatisfactory. Cognitive behavioral therapy, psychotherapy and hypnotherapy can help by providing a global therapeutic approach for IBS. This Viewpoint article discusses the available evidence for these behavioral therapies and highlights the benefits and the difficulties of using such approaches.

doi:10.1038/ncpgasthep1361 | Full Text | PDF (458K)

Pathogenesis of portal hypertensive gastropathy: translating basic research into clinical practice

Rafael F Perini, Paula RS Camara and Jose GP Ferraz

Portal hypertensive gastropathy (PHG) is often seen in patients with portal hypertension, and can lead to transfusion-dependent anemia as well as acute, life-threatening bleeding episodes. This Review article discusses the available knowledge regarding the mechanisms underlying the pathogenesis of PHG that provide reasonable grounds for the treatment of this condition, ultimately translating basic research into clinical practice.

doi:10.1038/ncpgasthep1356 | Full Text | PDF (674K)

Multimodal approaches to the treatment of hepatocellular carcinoma

Giuseppe Cabibbo, Federica Latteri, Michela Antonucci and Antonio Craxì

The prevalence of hepatocellular carcinoma (HCC) is increasing worldwide. Despite the use of aggressive treatments, the survival of patients with HCC is affected by tumor recurrence and the development of extrahepatic metastases. This Review discusses the available evidence for specific multimodal approaches in the treatment of HCC. Future directions of combinatory treatment approaches are also discussed.

doi:10.1038/ncpgasthep1357 | Full Text | PDF (553K)

Proteomic and metabolic prediction of response to therapy in gastrointestinal cancers

Ken Herrmann, Axel Walch, Benjamin Balluff, Marc Tänzer, Heinz Höfler, Bernd J Krause, Markus Schwaiger, Helmut Friess, Roland M Schmid and Matthias PA Ebert

The development of multimodality and targeted treatment strategies has improved the prognosis of patients with gastrointestinal cancers. Not all patients, however, benefit equally from these treatment approaches, and the ability to predict who will respond positively to a treatment type is of particular importance. This Review discusses the role of biomarkers and metabolic imaging approaches in the prediction of response to therapy early on in treatment.

doi:10.1038/ncpgasthep1366 | Full Text | PDF (896K)