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Nature Reviews Gastroenterology and Hepatology 5, 496–497 (1 September 2008) | doi:10.1038/ncpgasthep1200
What is the potential role of antifibrotic agents for the treatment of liver disease?
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Abstract
Liver fibrosis is characterized by the excessive deposition of extracellular matrix proteins, and results from chronic liver disease. The most important goal of antifibrotic therapy is to remove the fibrogenic stimulus by treating the underlying etiology of liver disease. The authors of this Viewpoint article discuss the promising targets for antifibrotic therapy that have been identified using animal models of liver fibrosis.
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