Mea culpa

Stephen B Hanauer

doi:10.1038/ncpgasthep1207 | Full Text | PDF (100K)

Supportive care might improve outcomes of patients with IBS

doi:10.1038/ncpgasthep1188 | Full Text | PDF (90K)

Adipocyte numbers are set during childhood and tightly regulated in adults

doi:10.1038/ncpgasthep1189 | Full Text | PDF (90K)

Probiotics might restore neutrophil function in patients with compensated cirrhosis

doi:10.1038/ncpgasthep1190 | Full Text | PDF (101K)

HRT use in the early postmenopausal period might reduce IBD activity

doi:10.1038/ncpgasthep1191 | Full Text | PDF (91K)

Terlipressin plus albumin improves renal function in patients with cirrhosis and HRS

doi:10.1038/ncpgasthep1192 | Full Text | PDF (103K)

Recombinant factor VIIa improves 42-day but not 5-day mortality from variceal bleeding

doi:10.1038/ncpgasthep1193 | Full Text | PDF (90K)

Risk of other autoimmune diseases is elevated in patients with IBD

doi:10.1038/ncpgasthep1194 | Full Text | PDF (93K)

H. pylori-induced gastric atrophy might protect against esophageal adenocarcinoma

doi:10.1038/ncpgasthep1195 | Full Text | PDF (93K)

Satisfactory outcomes for liver transplantation with elderly donors

doi:10.1038/ncpgasthep1196 | Full Text | PDF (93K)

Are capecitabine and oxaliplatin as effective as fluorouracil and cisplatin for gastroesophageal cancer?

Jaffer A Ajani

doi:10.1038/ncpgasthep1177 | Full Text | PDF (129K)

Is capsule endoscopy safe and useful for small-bowel surveillance in patients with familial adenomatous polyposis?

Xavier Dray and Patrice Valleur

doi:10.1038/ncpgasthep1186 | Full Text | PDF (128K)

What is the optimal bowel preparation for capsule endoscopy?

Zvi Fireman

doi:10.1038/ncpgasthep1180 | Full Text | PDF (126K)

Is percutaneous liver biopsy safe in patients with hepatitis C and end-stage renal disease?

Eric R Kallwitz and Scott J Cotler

doi:10.1038/ncpgasthep1183 | Full Text | PDF (128K)

Is adjuvant therapy for stage II colon cancer worthwhile, and for whom?

Neil H Segal and Leonard B Saltz

doi:10.1038/ncpgasthep1181 | Full Text | PDF (127K)

How effective is eltrombopag for the treatment of thrombocytopenia in patients with HCV infection?

James B Bussel and Kristen M Marks

doi:10.1038/ncpgasthep1185 | Full Text | PDF (132K)

Is it possible to modify the clinical course of Crohn's disease?

Sandro Ardizzone and Gabriele Bianchi Porro

The improvement of symptoms alone is no longer a satisfactory outcome for patients with Crohn's disease. The authors of this Viewpoint article argue that modification of the clinical course of Crohn's disease should be the major goal of medical therapy. Preliminary data suggest that the early use of biologics could achieve this aim in a subset of patients.

doi:10.1038/ncpgasthep1178 | Full Text | PDF (139K)

Coagulation, anticoagulation and pancreatic carcinoma

Inaam A Nakchbandi and J-Matthias Löhr

The authors of this Review present what is known about the pathophysiology of increased coagulation in patients with cancer and how it applies to pancreatic carcinoma. The relationship between the activation of coagulation or symptomatic thromboembolic disease and the development of pancreatic carcinoma is explored. In addition, the relationship between thromboembolic disease and prognosis, and the rationale and evidence for the use of anticoagulants in patients with pancreatic carcinoma are considered.

doi:10.1038/ncpgasthep1184 | Full Text | PDF (256K)

Mechanisms of Disease: inborn errors of bile acid synthesis

Shikha S Sundaram, Kevin E Bove, Mark A Lovell and Ronald J Sokol

Inborn errors of bile acid synthesis can present as neonatal cholestasis, neurologic disease or fat-soluble-vitamin deficiencies. In this Review, the authors discuss what we now know about the mechanisms underlying these disorders thanks to the application of modern biochemical and molecular techniques, the importance of early diagnosis, and the treatment options currently available.

doi:10.1038/ncpgasthep1179 | Full Text | PDF (717K)

Generalized peripheral lymphadenopathy in a patient treated for chronic HCV infection

Carlos Noronha Ferreira, Elidio R Barjas, Luis A Correia, Luis Tavares, Cristina Ferreira, Fatima L Serejo, Miguel Carneiro de Moura and Estela Monteiro

This article considers the case of a 62-year-old white woman who presented with a 2-month history of progressive, painless, left supraclavicular and axillary lymph node enlargement. Her history was significant for chronic HCV infection, for which she had just completed a 48-week course of treatment with pegylated interferon [alpha] plus ribavirin. Granulomatous lymphadenitis with sarcoid and tuberculoid granulomas was diagnosed and anti-tuberculosis treatment initiated with a successful outcome.

doi:10.1038/ncpgasthep1176 | Full Text | PDF (383K)