Table of contents
January 2006 Volume 3 No 1
Viewpoints
Do we need to rethink fundoplication for patients who have failed proton-pump-inhibitor therapy?
2This Viewpoint discusses the role of combined multichannel intraluminal impedance-pH testing in the evaluation of patients with GERD symptoms that are refractory to proton-pump-inhibitor therapy. The relationship between symptoms and reflux is important as symptoms might not be due to continuing reflux, and these patients therefore might not benefit from surgery.
Gastric fundal varices: new aspects of nonsurgical treatment in Japan
4Bleeding from gastric varices is a life-threatening event that presents a therapeutic challenge for clinicians. This Viewpoint discusses the advance in nonsurgical treatment of gastric fundal varices, including the new radiologic technique of balloon-occluded retrograde transvenous obliteration.
Research Highlights
Measuring bone mineral density in celiac disease patients
6Collis–Nissen procedure superior to Nissen fundoplication for Barrett's esophagus
6Risk of atherosclerosis in patients with inflammatory bowel disease
6Laparoscopic ileal-pouch–anal anastomosis is safe and effective
7Outcomes of living, adult, right-lobe liver donors
7Budesonide in the treatment of autoimmune hepatitis
8Hospitalization rates increase after gastric-bypass surgery
8Efficacy of sacral-nerve stimulation for treatment of fecal incontinence
9TRAIL mediates hepatic steatosis in viral hepatitis and following alcohol intake
9Diagnosis of cystic pancreatic tumors by endoscopic ultrasound-guided needle biopsy
9Clinical manifestations and treatment of food-cobalamin malabsorption in the elderly
10Small gallstones increase the risk of acute pancreatitis
10doi:10.1038/ncpgasthep0356 | Full Text | PDF (110K)
New model predicts patient survival after surgical resection for gastric cancer
12Screening for hereditary hemochromatosis in the primary-care setting
12Practice Points
How useful and accurate is the new Glasgow alcoholic hepatitis scoring system?
14Is laparoscopic Roux-en-Y gastric bypass superior to mini-gastric bypass for the treatment of morbid obesity?
16Is anatomic resection superior to nonanatomic resection for the treatment of patients with hepatocellular carcinoma?
18What is the optimal therapy for patients with Helicobacter pylori-negative dyspepsia?
20Reviews
Current management of peptic ulcer bleeding
24In the past 20 years the management of peptic ulcer bleeding has been revolutionized by effective endoscopic hemostasis and potent acid-suppressing agents. The author of this Review considers the roles that risk stratification, pharmacologic therapy, endoscopic therapy and surgery now have to play in the management of this common and potentially fatal condition.
doi:10.1038/ncpgasthep0388 | Full Text | PDF (178K)
Cholangiocarcinoma
33This Review discusses cholangiocarcinoma, the incidence of which is increasing globally. There are several established risk factors for cholangiocarcinoma, and others are now being recognized. Diagnosis requires the integration of clinical information, imaging studies, tumor markers and histology. Surgery can be curative, but most patients have unresectable disease, in which case palliation can improve quality of life and might also improve survival.
doi:10.1038/ncpgasthep0389 | Full Text | PDF (251K)
Therapy Insight: approaching endoscopy in anticoagulated patients
43Optimal management of anticoagulant and antiplatelet agents during the periendoscopic period requires consideration, but limited prospective data mean that guidelines have largely relied on expert opinion. This Review summarizes the ASGE guidelines, details the relevant literature on which they are based, considers literature that has become available since their publication, and provides a framework for the management of periendoscopic anticoagulation.
doi:10.1038/ncpgasthep0387 | Full Text | PDF (185K)
Case Study
Biliary sludge and acute pancreatitis during pregnancy
53doi:10.1038/ncpgasthep0390 | Full Text | PDF (191K)
