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Do we need to rethink fundoplication for patients who have failed proton-pump-inhibitor therapy?

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References

  1. Castell DO et al. (2002) Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 97: 575–583

    Article  CAS  Google Scholar 

  2. Campos GM et al. (1999) Multivariate analysis of factors predicting outcome after laparoscopic Nissen fundoplication. J Gastrointest Surg 3: 292–300

    Article  CAS  Google Scholar 

  3. Swoger JM et al. (2005) Does surgical fundoplication improve chronic laryngeal symptoms and signs unresponsive to aggressive medical therapy? A prospective cohort study [abstract]. Gastroenterology 128 (Suppl 2): 95

    Google Scholar 

  4. Hinder RA et al. (2000) Surgical therapy for supraesophageal reflux complications of gastroesophageal reflux disease. Am J Med 108 (Suppl 1): 178–180

    Article  Google Scholar 

  5. Irwin RS et al. (2002) Chronic cough due to gastroesophageal reflux disease: failure to resolve despite total/near-total elimination of esophageal acid. Chest 121: 1132–1140

    Article  Google Scholar 

  6. Tutuian R et al. (2003) Multichannel intraluminal impedance in esophageal function testing and gastroesophageal reflux monitoring. J Clin Gastroenterol 37: 206–215

    Article  Google Scholar 

  7. Wiener GJ et al. (1988) The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring. Am J Gastroenterol 83: 358–361

    CAS  PubMed  Google Scholar 

  8. Mainie I et al. (2004) Symptoms on PPI therapy associated with non-acid, acid or no reflux [abstract]. Am J Gastroenterol 99 (Suppl): S14

    Google Scholar 

  9. Taghavi SA et al. (2005) Symptom association probability and symptom sensitivity index: preferable but still suboptimal predictors of response to high dose omeprazole. Gut 54: 1067–1071

    Article  CAS  Google Scholar 

  10. Sifrim D et al. (2005) Weakly acidic reflux in patients with chronic unexplained cough during 24 hour pressure, pH, and impedance monitoring. Gut 54: 449–454

    Article  CAS  Google Scholar 

  11. Mainie I et al. (2005) Reflux (acid or non-acid) detected by multichannel intraluminal impedance–pH testing predicts good symptom response from fundoplication [abstract]. Gastroenterology 128 (Suppl 2): 130

    Google Scholar 

Download references

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Correspondence to Inder Mainie.

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Dr Castell is a consultant for Sandhill® Scientific Inc, Highlands Ranch, CO.

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Mainie, I., Castell, D. Do we need to rethink fundoplication for patients who have failed proton-pump-inhibitor therapy?. Nat Rev Gastroenterol Hepatol 3, 2–3 (2006). https://doi.org/10.1038/ncpgasthep0363

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