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Oesophageal cancer

RNA editing of SLC22A3 mRNAs: causative relevance to familial ESCC?

Nature Reviews Gastroenterology & Hepatology volume 14, pages 569–570 (2017)Cite this article

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A new study reveals an involvement of SLC22A3 in the development of familial oesophageal squamous cell carcinoma (ESCC). Reduced expression of SLC22A3 is detected not only in ESCC tumours but also in non-tumour tissues of patients with familial ESCC. Interestingly, adenosine-to-inosine editing of SLC22A3 mRNA is proposed to drive early tumour invasion and metastasis, by inhibiting SLC22A3 expression.

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Figure 1: Suppression of SLC22A3 and A-to-I editing of SLC22A3 mRNA by ADAR2 promotes early onset and progression of familial ESCC.

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Acknowledgements

The author thanks J.M. Murray for critical reading of the manuscript. Research in the Nishikura lab is supported by grants from the NIH (R01GM040536 and R01CA175058), the Macula Vision Research Foundation and the Japan Society for the Promotion of Science (S13204). The author acknowledges services provided by Shared Facilities of The Wistar Cancer Center, which are supported by the National Cancer Institute (P30CA010815). The content is solely the responsibility of the author and does not necessarily represent the official views of the NIH.

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  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, 19104, Pennsylvania, USA

    Kazuko Nishikura

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  1. Kazuko Nishikura
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Correspondence to Kazuko Nishikura.

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Nishikura, K. RNA editing of SLC22A3 mRNAs: causative relevance to familial ESCC?. Nat Rev Gastroenterol Hepatol 14, 569–570 (2017). https://doi.org/10.1038/nrgastro.2017.102

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