Women are counselled that surgery for ulcerative colitis leads to infertility and that they could require assisted reproductive technology (ART) to conceive. But how successful is ART, compared with women who do not have a history of ulcerative colitis? New data suggests that ART is less effective in women with ulcerative colitis, but its success is not reduced after surgery to treat the disease.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Palomba, S. et al. Inflammatory bowel diseases and human reproduction: a comprehensive evidence-based review. World J Gastroenterol. 20, 7123–7136 (2014).
Tavernier, N. et al. Systematic review: fertility in non-surgically treated inflammatory bowel disease. Aliment. Pharmacol. Ther. 38, 847–853 (2013).
Mahadevan, U. Fertility and pregnancy in the patient with inflammatory bowel disease. Gut 55, 1198–1206 (2006).
Selinger, C. P. et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J. Crohns Colitis 7, e206–e213 (2013).
Pabby, V. et al. In vitro fertilization is successful in women with ulcerative colitis and ileal pouch anal anastomosis. Am. J. Gastroenterol. 110, 792–797 (2015).
Oza, S. S. et al. In vitro fertilization in women with inflammatory bowel disease is a successful as in women from the general infertility population. Clin. Gastroenterol. Hepatol. 13, 1641–1646 (2015).
Nørgård, B. M. et al. Live birth and adverse birth outcomes in women with ulcerative colitis and Crohn's disease receiving assisted reproduction: a 20-year nationwide cohort study. Gut 65, 767–776 (2016).
Cornish, J. et al. A meta-analysis on the influence of inflammatory bowel disease on pregnancy. Gut 56, 830–837 (2007).
Winger, E. E. et al. Treatment with adalimumab (Humira) and intravenous immunoglobulin improves pregnancy rates in women undergoing IVF. Am. J. Reprod. Immunol. 61, 113–120 (2009).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Kane, S. Assisted reproductive technology less successful in ulcerative colitis. Nat Rev Gastroenterol Hepatol 13, 318–320 (2016). https://doi.org/10.1038/nrgastro.2016.66
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2016.66
