Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hepatitis

After HCV cure, HBV cure?

Nature Reviews Gastroenterology & Hepatology volume 12, pages 376–378 (2015)Cite this article

Subjects

Current treatments efficiently control chronic HBV infection but they do not lead to its elimination. Now, Ebert and colleagues have shown that cellular inhibitor of apoptosis proteins (cIAPs) prevent TNF-mediated killing of infected hepatocytes and that cIAP antagonists might lead to HBV cure by promoting death of infected cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Potential mechanism of action of cIAP inhibitors on HBV-infected hepatocytes.

References

  1. Pawlotsky, J. M. et al. From non-A, non-B hepatitis to hepatitis C virus cure. J. Hepatol. 62 (Suppl.), S87–S99 (2015).

    Article  CAS  PubMed  Google Scholar 

  2. Zoulim, F. & Locarnini, S. Management of treatment failure in chronic hepatitis B. J. Hepatol. 56 (Suppl. 1), S112–S122 (2012).

    Article  CAS  PubMed  Google Scholar 

  3. Ebert, G. et al. Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus. Proc. Natl Acad. Sci. USA 112, 5797–5802 (2015).

    Article  CAS  PubMed  Google Scholar 

  4. Wang, K. & Lin, B. Inhibitor of apoptosis proteins (IAPs) as regulatory factors of hepatic apoptosis. Cell Signal. 25, 1970–1080 (2013).

    Article  CAS  PubMed  Google Scholar 

  5. Thimme, R. et al. CD8+ T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J. Virol. 77, 68–76 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ebert, G. et al. Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis. Proc. Natl Acad. Sci. USA 112, 5803–5808 (2015).

    Article  CAS  PubMed  Google Scholar 

  7. Lan, P. et al. Therapeutic recovery of hepatitis B virus (HBV)-induced hepatocyte-intrinsic immune defect reverses systemic adaptive immune tolerance. Hepatology 58, 73–85 (2013).

    Article  CAS  PubMed  Google Scholar 

  8. Wisskirchen, K. et al. New pharmacological strategies to fight enveloped viruses. Trends Pharmacol. Sci. 35, 470–478 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Lucifora, J. et al. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science 343, 1221–1228 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Koh, S. et al. Engineered HBV-specific T cells: disentangling antiviral from killing capacity [abstract G04]. J. Hepatol. 62 (Suppl. 2), S188 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM U1052, CNRS UMR_5286, Cancer Research Center of Lyon (CRCL), 151 Cours Albert Thomas, Lyon Cedex 03, 69424, France

    Julie Lucifora & Christian Trepo

Authors
  1. Julie Lucifora
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christian Trepo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christian Trepo.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lucifora, J., Trepo, C. After HCV cure, HBV cure?. Nat Rev Gastroenterol Hepatol 12, 376–378 (2015). https://doi.org/10.1038/nrgastro.2015.103

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2015.103

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research