Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Hepatocellular carcinoma

Low risk of HCC in patients who have PSC and cirrhosis

Nature Reviews Gastroenterology & Hepatology volume 11, pages 276–277 (2014)Cite this article

Subjects

Primary sclerosing cholangitis (PSC) is understood to be associated with an increased risk of malignancy in the bile ducts, gallbladder and colon. The risk of hepatocellular carcinoma in the setting of PSC, however, is not well defined. Zenouzi et al. provide an analysis of their experience in a recent article

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Classic 'onion skin' fibrosis, causing obliteration of the bile ducts in primary sclerosing cholangitis.

References

  1. Zenouzi, R. et al. Low risk of hepatocellular carcinoma in patients with primary sclerosing cholangitis with cirrhosis. Clin. Gastroenterol. Hepatol. http://dx.doi.org/10.1016/j.cgh.2014.02.008.

  2. El-Serag, H. B. Hepatocellular carcinoma. N. Engl. J. Med. 365, 1118–1127 (2011).

    Article  CAS  Google Scholar 

  3. Harnois, D. M. et al. Are patients with cirrhotic stage primary sclerosing cholangitis at risk for the development of hepatocellular cancer? J. Hepatol. 27, 512–516 (1997).

    Article  CAS  Google Scholar 

  4. Hytiroglou, P. et al. Macroregenerative nodules in a series of adult cirrhotic liver explants: issues of classification and nomenclature. Hepatology 21, 703–708 (1995).

    CAS  PubMed  Google Scholar 

  5. Mion, F., Grozel, L., Boillot, O., Paliard, P. & Berger, F. Adult cirrhotic liver explants: precancerous lesions and undetected small hepatocellular carcinomas. Gastroenterology 111, 1587–1592 (1996).

    Article  CAS  Google Scholar 

  6. Goss, J. A. et al. Orthotopic liver transplantation for primary sclerosing cholangitis. A 12-year single center experience. Ann. Surg. 225, 472–481 (1997).

    Article  CAS  Google Scholar 

  7. Tischendorf, J. J., Hecker, H., Kruger, M., Manns, M. P. & Meier, P. N. Characterization, outcome, and prognosis in 273 patients with primary sclerosing cholangitis: A single center study. Am. J. Gastroenterol. 102, 107–114 (2007).

    Article  Google Scholar 

  8. Burak, K. et al. Incidence and risk factors for cholangiocarcinoma in primary sclerosing cholangitis. Am. J. Gastroenterol. 99, 523–526 (2004).

    Article  Google Scholar 

  9. Eaton, J. E., Talwalkar, J. A., Lazaridis, K. N., Gores, G. J. & Lindor, K. D. Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management. Gastroenterology 145, 521–536 (2013).

    Article  CAS  Google Scholar 

  10. Razumilava, N., Gores, G. J. & Lindor, K. D. Cancer surveillance in patients with primary sclerosing cholangitis. Hepatology 54, 1842–1852 (2011).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Mayo Clinic, 200 First St. SW, Mayo Clinic, Rochester, 55901, MN, USA

    Andrea A. Gossard

  2. Arizona State University, 550 North 3rd Street, Phoenix, 85004, AZ, USA

    Keith D. Lindor

Authors
  1. Andrea A. Gossard
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Keith D. Lindor
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Keith D. Lindor.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gossard, A., Lindor, K. Low risk of HCC in patients who have PSC and cirrhosis. Nat Rev Gastroenterol Hepatol 11, 276–277 (2014). https://doi.org/10.1038/nrgastro.2014.47

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrgastro.2014.47

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing