Traditional surgical therapy for chronic pancreatitis includes drainage of the dilated pancreatic duct or segmental resection of affected pancreas. Another option gaining increasing favour is that of total pancreatectomy with islet autotransplantation (TPIAT). A consensus conference, with proceedings published in 2013, discusses the current state-of-the-art information surrounding this procedure, and outstanding questions.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Everhart, J. E. & Ruhl, C. E. Burden of digestive diseases in the United States part III: liver, biliary tract, and pancreas. Gastroenterology 136, 1134–1144 (2009).
Bellin, M. D. et al. Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest. Pancreatology http://dx.doi.org/10.1016/j.pan.2013.10.009.
Morgan, K. et al. Pain control and quality of life after pancreatectomy with islet autotransplantation for chronic pancreatitis. J. Gastrointest. Surg. 16, 129–133 (2012).
Sutherland, D. E., Matas, A. J. & Najarian, J. S. Pancreatic islet cell transplantation. Surg. Clin. North Am. 58, 365–382 (1978).
Sutton, J. M. et al. Total pancreatectomy and islet cell autotransplantation as a means of treating patients with genetically linked pancreatitis. Surgery 148, 676–685 (2010).
Sutherland, D. E. et al. Total pancreatectomy and islet autotransplantation for chronic pancreatitis. J. Am. Coll. Surg. 214, 409–424 (2012).
Webb, M. et al. Islet autotransplantation following total pancreatectomy: a long-term assessment of graft function. Pancreas 37, 282–287 (2008).
Bachmann, K. et al. Is the Whipple procedure harmful for long-term outcome in treatment of chronic pancreatitis? 15-years follow-up comparing the outcome after pylorus-preserving pancreatoduodenectomy and Frey procedure in chronic pancreatitis. Ann. Surg. 258, 815–820 (2013).
van der Gaag, N. A. et al. Functional and medical outcomes after tailored surgery for pain due to chronic pancreatitis. Ann. Surg. 255, 763–770 (2012).
Shapiro, A. M. et al. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355, 1318–1330 (2006).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
PowerPoint slides
Rights and permissions
About this article
Cite this article
Beilman, G. Is TPIAT the answer for treatment of chronic pancreatitis?. Nat Rev Gastroenterol Hepatol 11, 144–145 (2014). https://doi.org/10.1038/nrgastro.2014.11
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrgastro.2014.11
This article is cited by
-
Delayed Gastric Emptying (DGE) Following Total Pancreatectomy with Islet Auto Transplantation in Patients with Chronic Pancreatitis
Journal of Gastrointestinal Surgery (2015)