Nature Reviews Gastroenterology and Hepatology 10, 362-370 (June 2013) | doi:10.1038/nrgastro.2013.36

Subject Category: Pancreas

The role of protein synthesis and digestive enzymes in acinar cell injury

Craig D. Logsdon & Baoan Ji  About the authors


The exocrine pancreas is the organ with the highest level of protein synthesis in the adult—each day the pancreas produces litres of fluid filled with enzymes that are capable of breaking down nearly all organic substances. For optimal health, the pancreas must produce sufficient enzymes of the right character to match the dietary intake. Disruption of normal pancreatic function occurs primarily as a result of dysfunction of the acinar cells that produce these digestive enzymes, and can lead to acute or chronic diseases. For many years, the prevailing dogma has been that inappropriate intracellular activation of the digestive enzymes produced by acinar cells was the key to pancreatic inflammatory diseases, as digestive enzymes themselves are potentially harmful to the cells that secrete them. However, we now know that many stressors can affect pancreatic acinar cells, and that these stressors can independently trigger pancreatic pathology through various mechanisms. This Review focuses on protein synthesis and active digestive enzymes—two key stressors faced by the acinar cell that are likely to be the major drivers of pathology encountered in the pancreas.

Author affiliations

C. D. Logsdon & B. Ji
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 953, Houston, TX 77030, USA (C. D. Logsdon). Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA (B. Ji).

Correspondence to: C. D. Logsdon

Published online 19 March 2013

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