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Nature Reviews Gastroenterology and Hepatology 1, 12–13 (1 November 2004) | doi:10.1038/ncpgasthep0006

What is the long-term effect of high-dose versus standard-dose omeprazole in patients with dyspepsia?

Stuart J Spechler

Meineche-Schmidt V (2004) Empiric treatment with high and standard dose of omeprazole in general practice: two-week randomized placebo-controlled trial and 12-month follow-up of health-care consumption. Am J Gastroenterol 99: 1059–1062 Synopsis Background Few patients presenting with acid-related symptoms for the first time are referred for endoscopy by their general practitioner (GP).