Nature Reviews Gastroenterology & Hepatology

Volume 14, No 7 July 2017


Consensus Statement

Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Glenn R. Gibson, Robert Hutkins, Mary Ellen Sanders, Susan L. Prescott, Raylene A. Reimer, Seppo J. Salminen, Karen Scott, Catherine Stanton, Kelly S. Swanson, Patrice D. Cani, Kristin Verbeke & Gregor Reid

With the continued interest in the role of the gut microbiota in health, attention has now turned to how to harness the microbiota for the benefit of the host. This Consensus Statement outlines the definition and scope of the term 'prebiotic' as determined by an expert panel convened by the International Scientific Association for Probiotics and Prebiotics in December 2016.

Front cover of the current issue of Nature Reviews Gastroenterology and Hepatology

2016 2-year Impact Factor 13.678 Journal Metrics 2-year Median 8

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Gut microbiota and IBD: causation or correlation?

Josephine Ni, Gary D. Wu, Lindsey Albenberg & Vesselin T. Tomov

Changes in the composition and metabolic function of the gut microbiota have been linked to IBD, but a direct causal association has yet to be established in humans. This Review discusses the evidence supporting dysbiosis in the gut microbiota in Crohn's disease and ulcerative colitis, exploring evidence from animal models and the translation to human disease.

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The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform

George S. Hussey, Timothy J. Keane & Stephen F. Badylak

Owing to its unique composition and influence on numerous biological processes, the extracellular matrix (ECM) is an ideal therapeutic substrate for tissue repair. In this Review, the authors provide an overview of ECM bioscaffolds derived from gastrointestinal tissues, and discuss advances in regenerative medicine using these scaffolds for the reconstruction of functional gastrointestinal tissues.

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Medical devices for the treatment of obesity

Phong Ching Lee & John Dixon

Combating the obesity epidemic necessitates a range of effective therapies. In this Review, Dixon and Lee explore the medical devices developed to bridge the gap between conservative lifestyle and pharmacotherapy interventions and disruptive surgical approaches, focusing on mechanisms of action, efficacy and safety.

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News and Views

IBD: To switch or not to switch: that is the biosimilar question

Silvio Danese & Laurent Peyrin-Biroulet

Biosimilar monoclonal antibodies are now being accepted in clinical practice by IBD specialists. However, switching patients already undergoing originator biologic treatment to biosimilars has been debated due to lack of controlled studies. The NOR-SWITCH study now provides novel clinical evidence in switching from originator to biosimilar in patients with IBD.


Nature Reviews cover competition 2018

Wanted: eye-catching images to feature on the covers of our 2018 issues of the clinical Nature Reviews titles. We are offering the opportunity for your image to appear on the cover throughout 2018! The owners of the chosen images will also receive a one year personal online subscription to the relevant journal and a print of their cover as a thank you. Good luck and we look forward to seeing your images!

Cancer Evolution

In this collection, the cancer editorial community of the Nature journals presents the most recently published articles on cancer evolution. The topic is discussed from different complementary angles (preclinical, translational and clinical), and across a broad range of tumour types.

Key Advances in Medicine eBook

The world of medicine is fast-paced and ever-changing; the Key Advances in Medicine eBook is bursting with information for medical students, physicians and clinical researchers wishing to keep up with the most significant medical breakthroughs of the past year. This eBook, which is free to download for registered users, contains 45 articles summarizing the key clinical and biomedical studies published in 2016 and highlighting the trends to watch out for in 2017. The articles are written by international experts who identify the top ground-breaking research papers within their speciality.

Article series on cell & developmental biology in the digestive system

In this article series, Nature Reviews Gastroenterology & Hepatology explores different cell biology and developmental pathways involved in gastrointestinal health and disease, the role of stem and progenitor cells in tissue development and regeneration and recent advances in bioengineering, which might shape clinical approaches in the near future.

Optical imaging collection

The evolution of optical technologies for diagnostic imaging has revolutionized the understanding, detection and treatment of disease. This Collection of recent content published in Nature journals brings together advances in the field and highlights their impact in the clinic.

Fibrosis collection

This collection consists of Reviews and Research articles from several Nature journals, describing the latest advances in fibrosis research in various organs, including the liver, kidney, heart, skin and lung. It also includes relevant News and Opinion articles and additional content, including a selection of peer-reviewed procedures from Nature Protocols, and a PrimeView, which summarizes the main features of systemic sclerosis.

Focus on Coeliac disease & gluten sensitivity

Awareness and understanding of gluten-related disorders (including coeliac disease and noncoeliac gluten sensitivity) has improved over the past few decades, with insights into the immunopathogenesis and genetics, as well as in serology, diagnosis, clinical features and management. These specially commissioned articles, written by key opinion leaders in the field, highlight new understanding of coeliac disease and gluten sensitivity, including pathogenesis, overlap with other autoimmune diseases, gluten-related disorders in childhood, extraintestinal manifestations, refractory disease, practical insights into a gluten-free diet and the debate around noncoeliac gluten sensitivity.

A decade in medicine eBook

The past 10 years has seen great advances in the understanding and treatment of human disease. For expert perspectives on the most important breakthroughs, don't miss the A Decade in Medicine eBook. In this special collection of 47 articles—commissioned to celebrate the 10th anniversary of the launch of the clinical Nature Reviews journals—leading experts highlight the most important advances in eight medical specialties between 2004 and 2015, and comment on future developments in their fields. The A Decade in Medicine eBook is FREE to download for registered users.

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Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.


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