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Perianal fistulizing Crohn's disease: pathogenesis, diagnosis and therapy

Latest Reviews

  • Review |

    Chronic opioid use is increasing worldwide and has negative effects in the gastrointestinal and central nervous systems. This Review summarizes the evidence and consequences of opioid misuse in gastroenterology, as well as alternative pharmacological and nonpharmacological strategies for pain management in patients with gastrointestinal disorders.

    • Eva Szigethy
    • , Mitchell Knisely
    •  & Douglas Drossman
  • Consensus Statement | | open

    Environmental enteric dysfunction (EED) is an important cause of impaired development and stunting in children in the developing world. In this Consensus Statement, the authors assess the potential of optical biopsy technologies to facilitate the study and diagnosis of this global burden.

    • Alex J. Thompson
    • , Michael Hughes
    • , Salzitsa Anastasova
    • , Laurie S. Conklin
    • , Tudor Thomas
    • , Cadman Leggett
    • , William A. Faubion
    • , Thomas J. Miller
    • , Peter Delaney
    • , François Lacombe
    • , Sacha Loiseau
    • , Alexander Meining
    • , Rebecca Richards-Kortum
    • , Guillermo J. Tearney
    • , Paul Kelly
    •  & Guang-Zhong Yang
  • Review |

    A wide variety of environmental triggers have been associated with IBD pathogenesis, including the gut microbiota, diet, pollution and early-life factors. This Review discusses the latest evidence and progress towards better understanding the environmental factors associated with IBD.

    • Ashwin N. Ananthakrishnan
    • , Charles N. Bernstein
    • , Dimitrios Iliopoulos
    • , Andrew Macpherson
    • , Markus F. Neurath
    • , Raja A. Raja Ali
    • , Stephan R. Vavricka
    •  & Claudio Fiocchi
  • Review |

    Bile acids link the gut microbiota to both hepatic and intestinal metabolism, and this tripartite relationship has been implicated in gastrointestinal disease. In this Review, the authors outline the mechanistic links between bile acid–microbiota crosstalk and gastrointestinal inflammation and carcinogenesis, with a specific emphasis on the major bile-acid-sensing receptors.

    • Wei Jia
    • , Guoxiang Xie
    •  & Weiping Jia
  • Review |

    Following haematopoietic stem cell transplantation for the treatment of haematopoietic diseases, acute graft-versus-host disease (GVHD) of the gastrointestinal tract is a common complication that presents distinct diagnostic and therapeutic challenges. In this Review, the authors tailor their discussion of the diagnosis, staging and clinical management of gastrointestinal acute GVHD for practising gastroenterologists.

    • Steven Naymagon
    • , Leonard Naymagon
    • , Serre-Yu Wong
    • , Huaibin Mabel Ko
    • , Anne Renteria
    • , John Levine
    • , Jean-Frederic Colombel
    •  & James Ferrara
  • Consensus Statement | | open

    The diagnosis of GERD using functional oesophageal testing has been previously reported, but no updated expert recommendations have been made in over a decade. In this Consensus Statement, the authors describe modern oesophageal physiological tests and their analysis with an emphasis on establishing indications and interpretation parameters for evaluating GERD in clinical practice.

    • Edoardo Savarino
    • , Albert J. Bredenoord
    • , Mark Fox
    • , John E. Pandolfino
    • , Sabine Roman
    • , C. Prakash Gyawali
    •  & on behalf of the International Working Group for Disorders of Gastrointestinal Motility and Function

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NAFLD and NASH

Caio Bracey

NAFLD and NASH

Fuelled by increasing obesity rates, NAFLD has emerged as a leading global cause of chronic liver disease in the past few decades. Despite growing prevalence, the factors influencing NAFLD development and subsequent progression to NASH, liver fibrosis, cirrhosis and hepatocellular carcinoma are poorly understood. In this article series, Nature Reviews Gastroenterology & Hepatology explores the epidemiology of NAFLD, disease mechanisms and therapeutics, and clinical approaches to diagnosis and management.

Hugh Thomas

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