Modes of transcriptional regulation

How genes are switched on and off at the correct time and in the correct place is a crucial and enduring question for researchers. Advances in our ability to characterize protein–DNA and protein–protein interactions, the dynamics of chromatin structure and transcriptional output under different conditions have substantially enhanced understanding in this area. The articles in this series consider the range of levels at which transcription is controlled, the molecules involved and how the modes of regulation are adapted to particular types of gene or developmental contexts.


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2017

June 2017 Volume 18 No 6

The X chromosome in space

Teddy Jégu, Eric Aeby & Jeannie T. Lee

doi:10.1038/nrg.2017.17

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2015

November 2015 Volume 16 No 11

Exploring the emerging complexity in transcriptional regulation of energy homeostasis

Adelheid Lempradl, J. Andrew Pospisilik & Josef M. Penninger

doi:10.1038/nrg3941

November 2015 Volume 16 No 11

Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation

Björn Reinius & Rickard Sandberg

doi:10.1038/nrg3888

March 2015 Volume 16 No 3

Chromatin regulation at the frontier of synthetic biology

Albert J. Keung, J. Keith Joung, Ahmad S. Khalil & James J. Collins

doi:10.1038/nrg3900

February 2015 Volume 16 No 2

RNA-mediated epigenetic regulation of gene expression

Daniel Holoch & Danesh Moazed

doi:10.1038/nrg3863

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2014

November 2014 Volume 15 No 11

Evolutionary dynamics of coding and non-coding transcriptomes

Anamaria Necsulea & Henrik Kaessmann

doi:10.1038/nrg3802

July 2014 Volume 15 No 7

In pursuit of design principles of regulatory sequences

Michal Levo & Eran Segal

doi:10.1038/nrg3684

April 2014 Volume 15 No 4

CTCF: an architectural protein bridging genome topology and function

Chin-Tong Ong & Victor G. Corces

doi:10.1038/nrg3663

April 2014 Volume 15 No 4

Evolution of transcription factor binding in metazoans — mechanisms and functional implications

Diego Villar, Paul Flicek & Duncan T. Odom

doi:10.1038/nrg3481

February 2014 Volume 15 No 2

Chromatin modifiers and remodellers: regulators of cellular differentiation

Taiping Chen & Sharon Y. R. Dent

doi:10.1038/nrg3607

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2013

August 2013 Volume 14 No 8

Eukaryotic transcriptional dynamics: from single molecules to cell populations

Antoine Coulon, Carson C. Chow, Robert H. Singer & Daniel R. Larson

doi:10.1038/nrg3484

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2012

October 2012 Volume 13 No 10

Promoter-proximal pausing of RNA polymerase II: emerging roles in metazoans

Karen Adelman & John T. Lis

doi:10.1038/nrg3293

September 2012 Volume 13 No 9

Transcription factors: from enhancer binding to developmental control

François Spitz & Eileen E. M. Furlong

doi:10.1038/nrg3207

June 2012 Volume 13 No 6

Mechanisms and consequences of widespread random monoallelic expression

Andrew Chess

doi:10.1038/nrg3239

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2011

December 2011 Volume 12 No 12

Controlling gene expression in response to stress

Eulàlia de Nadal, Gustav Ammerer & Francesc Posas

doi:10.1038/nrg3055

August 2011 Volume 12 No 8

Determinants and dynamics of genome accessibility

Oliver Bell, Vijay K. Tiwari, Nicolas H. Thomä & Dirk Schübeler

doi:10.1038/nrg3017

April 2011 Volume 12 No 4

Enhancer function: new insights into the regulation of tissue-specific gene expression

Chin-Tong Ong & Victor G. Corces

doi:10.1038/nrg2957

February 2011 Volume 12 No 3

Silencing chromatin: comparing modes and mechanisms

Christian Beisel & Renato Paro

doi:10.1038/nrg2932

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2010

December 2010 Volume 11 No 12

Regulation of transcription in plants: mechanisms controlling developmental switches

Kerstin Kaufmann, Alice Pajoro & Gerco C. Angenent

doi:10.1038/nrg2885

November 2010 Volume 11 No 11

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

Sohail Malik & Robert G. Roeder

doi:10.1038/nrg2901

August 2010 Volume 11 No 8

Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation

James A. Goodrich & Robert Tjian

doi:10.1038/nrg2847

June 2010 Volume 11 No 6

Inducible gene expression: diverse regulatory mechanisms

Vikki M. Weake & Jerry L. Workman

doi:10.1038/nrg2781

February 2010 Volume 11 No 2

Deconstructing repression: evolving models of co-repressor action

Valentina Perissi, Kristen Jepsen, Christopher K. Glass & Michael G. Rosenfeld

doi:10.1038/nrg2736