Regulatory elements

The function of the genome crucially involves regulatory sequences, such as enhancers and promoters. Many questions remain unanswered as to how these regulatory elements work, and even identifying them can be a major challenge. New genomic technologies — including transcriptomics, genome sequencing and chromatin immunoprecipitation followed by sequencing — are enabling progress in this field. The articles in this series discuss recent views on regulatory elements, including their role in evolution and the function of chromatin modifications, as well as methods to study these important regions of the genome.


Top

2017

May 2017 Volume 18 No 5

Integration site selection by retroviruses and transposable elements in eukaryotes

Tania Sultana, Alessia Zamborlini, Gael Cristofari & Pascale Lesage

doi:10.1038/nrg.2017.7

February 2017 Volume 18 No 2

Regulatory activities of transposable elements: from conflicts to benefits

Edward B. Chuong, Nels C. Elde & Cédric Feschotte

doi:10.1038/nrg.2016.139

Top

2016

April 2016 Volume 17 No 4

Enhancers as non-coding RNA transcription units: recent insights and future perspectives

Wenbo Li, Dimple Notani & Michael G. Rosenfeld

doi:10.1038/nrg.2016.4

Top

2014

July 2014 Volume 15 No 7

In pursuit of design principles of regulatory sequences

Michal Levo & Eran Segal

doi:10.1038/nrg3684

Arpil 2014 Volume 15 No 4

Transcriptional enhancers: from properties to genome-wide predictions

Daria Shlyueva, Gerald Stampfel & Alexander Stark

doi:10.1038/nrg3682

Top

2013

April 2013 Volume 14 No 4

Enhancers: five essential questions

Len A. Pennacchio, Wendy Bickmore, Ann Dean, Marcelo A. Nobrega & Gill Bejerano

doi:10.1038/nrg3458

Top

2012

July 2012 Volume 13 No 7

Genomic approaches towards finding cis-regulatory modules in animals

Ross C. Hardison & James Taylor

doi:10.1038/nrg3242

April 2012 Volume 13 No 4

Metazoan promoters: emerging characteristics and insights into transcriptional regulation

Boris Lenhard, Albin Sandelin & Piero Carninci

doi:10.1038/nrg3163

January 2012 Volume 13 No 1

Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence

Patricia J. Wittkopp & Gizem Kalay

doi:10.1038/nrg3095

Top

2011

April 2011 Volume 12 No 4

Enhancer function: new insights into the regulation of tissue-specific gene expression

Chin-Tong Ong & Victor G. Corces

doi:10.1038/nrg2957

January 2011 Volume 12 No 1

Charting histone modifications and the functional organization of mammalian genomes

Vicky W. Zhou, Alon Goren & Bradley E. Bernstein

doi:10.1038/nrg2905

Top

2010

August 2010 Volume 11 No 8

Annotating non-coding regions of the genome

Roger P. Alexander, Gang Fang, Joel Rozowsky, Michael Snyder & Mark B. Gerstein

doi:10.1038/nrg2814

June 2010 Volume 11 No 6

Insulators and promoters: closer than we think

Jesse R. Raab & Rohinton T. Kamakaka

doi:10.1038/nrg2765

Extra navigation

natureevents

Advertisment