Modelling

An abundance of data and unprecedented computational power are allowing sophisticated biological models to be devised and tested. This series of articles examines how the coupling of genetics with disciplines such as engineering, statistics, physics and computational biology has enriched our understanding in areas that range from developmental patterning to genetic association analyses.


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2016

February 2016 Volume 17No 2

Causes of evolutionary rate variation among protein sites

Julian Echave, Stephanie J. Spielman & Claus O. Wilke

doi:10.1038/nrg.2015.18

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2015

March 2015 Volume 16 No 3

Quantitative and logic modelling of molecular and gene networks

Nicolas Le Novère

doi:10.1038/nrg3885

February 2015 Volume 16 No 2

Competition between target sites of regulators shapes post-transcriptional gene regulation

Marvin Jens & Nikolaus Rajewsky

doi:10.1038/nrg3853

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2014

February 2014 Volume 15 No 2

Constraint-based models predict metabolic and associated cellular functions

Aarash Bordbar, Jonathan M. Monk, Zachary A. King & Bernhard O. Palsson

doi:10.1038/nrg3643

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2012

March 2012 Volume 13 No 3

Cellular genomics for complex traits

Emmanouil T. Dermitzakis

doi:10.1038/nrg3115

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2011

September 2011 Volume 12 No 9

Systems-biology approaches for predicting genomic evolution

Balázs Papp, Richard A. Notebaart & Csaba Pál

doi:10.1038/nrg3033

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2010

September 2010 Volume 11 No 9

Evolution and development of shape: integrating quantitative approaches

Christian Peter Klingenberg

doi:10.1038/nrg2829

April 2010 Volume 11 No 4

Towards genome-scale signalling-network reconstructions

Daniel R. Hyduke & Bernhard Ø. Palsson

doi:10.1038/nrg2750

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2009

December 2009 Volume 10 No 12

Synthetic biology: understanding biological design from synthetic circuits

Shankar Mukherji & Alexander van Oudenaarden

doi:10.1038/nrg2697

October 2009 Volume 10 No 10

Bayesian statistical methods for genetic association studies

Matthew Stephens & David J. Balding

doi:10.1038/nrg2615

September 2009 Volume 10 No 9

Microfluidic devices for measuring gene network dynamics in single cells

Matthew R. Bennett & Jeff Hasty

doi:10.1038/nrg2625

August 2009 Volume 10 No 8

Quantitative approaches in developmental biology

Andrew C. Oates, Nicole Gorfinkiel, Marcos González–Gaitán & Carl–Philipp Heisenberg

doi:10.1038/nrg2548

August 2009 Volume 10 No 8

Evolutionary analysis of the dynamics of viral infectious disease

Oliver G. Pybus & Andrew Rambaut

doi:10.1038/nrg2583

July 2009 Volume 10 No 7

From DNA sequence to transcriptional behaviour: a quantitative approach

Eran Segal & Jonathan Widom

doi:10.1038/nrg2591

June 2009 Volume 10 No 6

Detecting gene–gene interactions that underlie human diseases

Heather J. Cordell

doi:10.1038/nrg2579

February 2009 Volume 10 No 2

Stochastic modelling for quantitative description of heterogeneous biological systems

Darren J. Wilkinson

doi:10.1038/nrg2509

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