Animation and slideshow

RNA interference

Our knowledge of RNA interference — popularly known as RNAi — has expanded dramatically in the short time since its discovery. Several types of small silencing RNAs have now been discovered, including small interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs).

Small RNAs are involved in regulating gene expression in many ways, and RNAi is being harnessed by scientists for laboratory research and for the development of new therapies for disease.

This animation introduces the principles of RNAi involving siRNAs and miRNAs. We take you on an audio-visual journey through the steps of gene expression and give an up-to-date view of how RNAi can silence specific mRNAs in the cytoplasm.

Extra information about RNAi is provided in an accompanying slideshow.

View the FREE animation and slideshow

Scientific adviser: Craig C. Mello, University of Massachusetts Medical School, Worcester, USA.
Animation by Arkitek Studios.

The animation and slideshow are freely available thanks to support from Dharmacon, part of GE Healthcare. For information about RNAi solutions from the sponsor, please click here.

View a FREE poster on 'Tools for studying and using small RNAs: from pathways to functions to therapies'

To learn more about RNAi, visit the Nature Review Genetics Series on Non-coding RNA