Advance online publication

The latest articles are published online ahead of print (AOP) on a weekly basis. These online versions are definitive and may be cited using the digital object identifier (DOI).


24 July 2017

Research Highlights

Alternative splicing: A thermometer controlling gene expression | PDF (146 KB)

Published online: 24 July 2017 | doi:10.1038/nrg.2017.61

Genome organization: Tracking chromosomal conformation through the cell cycle | PDF (204 KB)

Published online: 24 July 2017 | doi:10.1038/nrg.2017.62



Dissecting evolution and disease using comparative vertebrate genomics

Jennifer R. S. Meadows & Kerstin Lindblad-Toh

Published online: 24 July 2017 | doi:10.1038/nrg.2017.51

The last 25 years has seen a revolution in sequencing, with more than 100 vertebrate genome sequences now available. In this Review, Meadows and Lindblad-Toh discuss how the genomics of non-human organisms can provide insights into vertebrate biology and conservation, and how they can contribute to the understanding of human health and disease.


17 July 2017


Evolutionary biology through the lens of budding yeast comparative genomics

Souhir Marsit, Jean-Baptiste Leducq, Éléonore Durand, Axelle Marchant, Marie Filteau & Christian R. Landry

Published online: 17 July 2017 | doi:10.1038/nrg.2017.49

Saccharomyces cerevisiae has become an important model organism in the field of evolutionary genomics. Comparative genomic analysis of laboratory, wild and domesticated yeast populations is generating insights into how new species form and how populations adapt to their environments.

The impact of replication stress on replication dynamics and DNA damage in vertebrate cells

Hervé Técher, Stéphane Koundrioukoff, Alain Nicolas & Michelle Debatisse

Published online: 17 July 2017 | doi:10.1038/nrg.2017.46

Recent studies have provided insights into the sources of endogenous replication stress, which can result in DNA damage, checkpoint activation and genome-wide replication fork slowing. The authors review established mechanisms involved in the replication stress response, and propose a new model that reconciles data gained from different cellular models.


03 July 2017


Article series: Epigenetics

Exploiting induced and natural epigenetic variation for crop improvement

Nathan M. Springer & Robert J. Schmitz

Published online: 03 July 2017 | doi:10.1038/nrg.2017.45

To unlock the potential of epigenetic variation for crop improvement, it will be crucial to understand how epigenetic variation is established and how it is stably inherited across generations. Springer and Schmitz review these challenges, the different sources of epigenetic variation in plants, and how epigenome profiling and engineering could help to improve crops.


26 June 2017


Synthetic lethality and cancer

Nigel J. O'Neil, Melanie L. Bailey & Philip Hieter

Published online: 26 June 2017 | doi:10.1038/nrg.2017.47

The authors review the concept of synthetic lethality — when the perturbation of one of two genes alone is viable, but the perturbation of both genes simultaneously results in the loss of viability — from model organisms to human cancers, and discuss how genetic interactions can be exploited for the identification of new drug targets in cancer.


12 June 2017


Network propagation: a universal amplifier of genetic associations

Lenore Cowen, Trey Ideker, Benjamin J. Raphael & Roded Sharan

Published online: 12 June 2017 | doi:10.1038/nrg.2017.38

Network propagation is based on the principle that genes underlying similar phenotypes are more likely to interact with each other. It is proving to be a powerful approach for extracting biological information from molecular networks that is relevant to human disease.


30 May 2017


Article series: Epigenetics

TET-mediated active DNA demethylation: mechanism, function and beyond

Xiaoji Wu & Yi Zhang

Published online: 30 May 2017 | doi:10.1038/nrg.2017.33

A key mode of regulating DNA methylation is through active demethylation driven by TET-mediated oxidation of 5-methylcytosine (5mC). This Review discusses our latest understanding of the mechanisms and regulation of active DNA demethylation, and the roles of active demethylation (and the oxidized 5mC intermediates) in gene regulation, genome stability, development and disease.


About AOP

Until print versions of AOP papers are published, they should be cited in the style "Nature Reviews Genetics AOP, published online day month year; doi:10.1038/nrgXXX". Once the print version (identical to the AOP) is published, it should be cited as follows: "Nature Reviews Genetics volume number, page range (year); doi:10.1038/nrgXXX".