Abstract

The molecular, genetic and cellular bases for skeletal muscle growth and regeneration have been recently documented in a number of vertebrate species. These studies highlight the role of transient subcompartments of the early somite as a source of distinct waves of myogenic precursors. Individual myogenic progenitor populations undergo a complex series of cell rearrangements and specification events in different regions of the body, all of which are controlled by distinct gene regulatory networks. Collectively, these studies have opened a window into the morphogenetic and molecular bases of the different phases of vertebrate myogenesis, from embryo to adult.

Author affiliations

1. Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia.
2. School of Medical Sciences, Faculty of Medicine, Wallace Wurth Building, University of New South Wales, Sydney, New South Wales 2052, Australia.
   Email: r.bryson-richardson@victorchang.edu.au
3. St Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Level 5, de Lacy Building, Victoria Street, St Vincent's Hospital, Darlinghurst New South Wales 2010, Australia.
   Email: p.currie@victorchang.edu.au

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