Nature Reviews Genetics 9, 341-355 (May 2008) | doi:10.1038/nrg2346

There is a Corrigendum (1 June 2008) associated with this article.

Advances in autism genetics: on the threshold of a new neurobiology

Brett S. Abrahams1 & Daniel H. Geschwind1  About the authors


Autism is a heterogeneous syndrome defined by impairments in three core domains: social interaction, language and range of interests. Recent work has led to the identification of several autism susceptibility genes and an increased appreciation of the contribution of de novo and inherited copy number variation. Promising strategies are also being applied to identify common genetic risk variants. Systems biology approaches, including array-based expression profiling, are poised to provide additional insights into this group of disorders, in which heterogeneity, both genetic and phenotypic, is emerging as a dominant theme.

Author affiliations

  1. Programs in Neurogenetics and Neurobehavioural Genetics, Neurology Department, and Semel Institute for Neuroscience and Behaviour, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095-1769 USA.

Correspondence to: Brett S. Abrahams1Daniel H. Geschwind1 Email:; Email:


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Nature Reviews Neuroscience Review (01 Jul 2010)

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Nature Genetics News and Views (01 Oct 2007)