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Nature Reviews Genetics 9, 159 (1 March 2008) | doi:10.1038/nrg2333

Technology: Colour-changing worms

Anne Blewett

Observing the real-time changes in gene expression that occur during the development of a living worm is now possible owing to a recent study by Ohno and colleagues. Using fluorescent proteins, the team visualized developmentally regulated changes in live nematodes during alternative pre-mRNA splicing, the process that produces proteome diversity from a finite number of genes.