Figures and Tables

From the following article:

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Keith W. Orford & David T. Scadden

Nature Reviews Genetics 9, 115-128 (February 2008)

doi:10.1038/nrg2269

Figure 1 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Figure 1

The cell cycle in embryonic stem cells.

Figure 2 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Figure 2

Loss of quiescence results in loss of function in adult stem cells.

Figure 3 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Figure 3

A possible mechanism linking early G1 transit with commitment or self-renewal.

Figure 4 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Figure 4

A model of niche regulation of stem cell proliferation and cell-fate decisions.

Figure 5 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Figure 5

Polycomb-mediated silencing of developmental genes imposes self-renewal by actively blocking stem cell differentiation.

Table 1 - Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Table 1

A summary of the main phenotypes of the genetic models discussed in the text