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Nature Reviews Genetics 9, 814–815 (1 November 2008) | doi:10.1038/nrg2477

Genome evolution: CNV evolution revisited

Tanita Casci

The size and sheer number of copy number variants (CNVs) in the human genome puts them on a par with SNPs for their potential importance to health and evolution. Previous reports had reasoned that CNVs were frequent because they were beneficial.